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How to get fromChicago to Great Smoky Mountainsby plane, car, bus, or train

Find Transport to Great Smoky Mountains

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There are 10 ways to get from Chicago to Great Smoky Mountains by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 23m
    $112–621

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    5h 43m
    $76–367

  3. Bus, drive

    1. Take the bus from Chicago Union Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    23h 31m
    $204–353

  4. Train, bus, drive

    1. Take the train from Chicago Union Station to Carytrain train
    2. Take the train from Cary to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Drive from Asheville, NC to Great Smoky Mountainscar car
    33h 5m
    $412–831

  5. Drive 582.1 mi

    1. Drive from Chicago to Great Smoky Mountainscar car 582.1 mi
    10h 59m
    $107–154

  6. Fly Chicago Midway International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    4h 54m
    $132–771

  7. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Great Smoky Mountainscar car
    6h 54m
    $122–590

  8. Fly Chicago O'Hare International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Great Smoky Mountainscar car
    7h 16m
    $140–695

  9. Fly Chicago Midway International Airport to Nashville, drive

    1. Fly from Chicago Midway International Airport (MDW) to Nashville (BNA)plane plane MDW - BNA
    2. Drive from Nashville-Airport-BNA to Great Smoky Mountainscar car
    7h 37m
    $112–510

  10. Bus, drive via Columbus

    1. Take the bus from Chicago to Columbus - Mound Stbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    4. Drive from New Leicester Hwy at Walgreens to Great Smoky Mountainscar car
    25h 2m
    $129–271

Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) flights

Calendar75Weekly Planes
Duration2h 58mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 552.4 mi
  • Duration: 5h 23m

What companies run services between Chicago, IL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Chicago to Great Smoky Mountains. However, you can take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take a bus from Chicago Union Station to Great Smoky Mountains via Toledo Bus Stop, Winston Salem(Trans Center), and Asheville, NC in around 23h 31m.

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