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How to get fromChicago to Greenvilleby plane, car, train, or bus

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There are 6 ways to get from Chicago to Greenville by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Bill And Hillary Clinton National Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Bill And Hillary Clinton National Airport (LIT)plane plane ORD - LIT
    2. Drive from Bill And Hillary Clinton National Airport (LIT) to Greenvillecar car
    6h 26m
    $88–395

  2. Train, drive (Amtrak)

    1. Take the train from Chicago Union Station to Greenwood Amtrak Stationtrain train City of New Orleans
    2. Drive from Greenwood Amtrak Station to Greenvillecar car
    14h 29m
    $219–443

  3. Bus, train, drive

    1. Take the bus from Chicago Bus Station to Memphis Bus Stationbus bus
    2. Take the bus from Memphis Bus Station to Jacksonbus bus
    3. Take the train from Jackson to Yazoo City Amtrak Stationtrain train
    4. Drive from Yazoo City Amtrak Station to Greenvillecar car
    17h 38m
    $139–271

  4. Drive 677.7 mi

    1. Drive from Chicago to Greenvillecar car 677.7 mi
    11h 24m
    $124–179

  5. Fly Chicago Midway International Airport to Greenville International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Greenville International Airport (GLH)plane plane MDW - GLH
    6h 12m
    $174–581

  6. Fly Chicago O'Hare International Airport to Greenville International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville International Airport (GLH)plane plane ORD - GLH
    7h 32m
    $114–461

Chicago O'Hare International Airport (ORD) to Bill And Hillary Clinton National Airport (LIT) flights

Calendar54Weekly Planes
Duration2h 39mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Greenville.ExpandLaunch map view
  • Distance: 717.9 mi
  • Duration: 6h 26m

What companies run services between Chicago, IL, USA and Greenville, MS, USA?

Frontier Airlines, Key Lime, and Southwest Airlines fly from Chicago Midway International Airport (MDW) to Greenville International Airport (GLH) once daily.

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