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How to get fromChicago to Harrisburgby plane, train (Amtrak), bus (Flixbus), car, taxi, bus, or bus (Greyhound)

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There are 7 ways to get from Chicago to Harrisburg by plane, train (Amtrak), bus (Flixbus), car, taxi, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT)plane plane ORD - MDT
    4h 47m
    $64–359

  2. Train (Amtrak)

    1. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    2. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train Pennsylvanian
    15h 50m
    $222–468

  3. Bus (Flixbus)

    1. Take the bus from Chicago to Harrisburg Bus Stationbus bus FlixBus N2640
    17h 18m
    $112–192

  4. Drive 655.6 mi

    1. Drive from Chicago to Harrisburgcar car 655.6 mi
    10h 53m
    $120–173

  5. Fly to Lancaster, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Lancaster (LNS)plane plane ORD - LNS
    2. Take the taxi from Lancaster-Airport-LNS to Harrisburgtaxi taxi
    4h 39m
    $178–505

  6. Fly to Penn State University Park Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Penn State University Park Airport (SCE)plane plane ORD - SCE
    2. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    6h 24m
    $72–368

  7. Bus via Baltimore (Greyhound)

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0164
    2. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus Greyhound US0430
    20h 30m
    $124–236

Chicago to Harrisburg by train (Amtrak)

Calendar7Weekly Trains
Duration15h 50mAverage Duration
Ticket$222Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Harrisburg.ExpandLaunch map view
  • Distance: 622.3 mi
  • Duration: 4h 47m

What companies run services between Chicago, IL, USA and Harrisburg, Dauphin County, PA, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT) hourly. Alternatively, you can take a train from Chicago Union Station to Harrisburg via Pittsburgh Amtrak Station in around 15h 50m.

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