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How to get fromChicago to Isle of Palmsby plane, bus (Greyhound, Flixbus), train (Amtrak), or car

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There are 6 ways to get from Chicago to Isle of Palms by plane, bus (Greyhound, Flixbus), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    4h 6m
    $192–665
  2. Drive 879.7 mi

    cheapest
    1. Drive from Chicago to Isle of Palmscar car 879.7 mi
    16h 9m
    $161–232
  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    28h 49m
    $239–420
  4. Train via Petersburg (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 50m
    $459–911
  5. Fly from Chicago O'Hare International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    4h 33m
    $172–525
  6. Train (Amtrak)

    1. Take the train from Chicago Union Station to Savannah Stationtrain train Floridian
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train Palmetto / ...
    34h 35m
    $540–1,072

Chicago Midway International Airport (MDW) to Charleston International Airport (CHS) flights

Calendar32Weekly Planes
Duration3h 35mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Isle of Palms, SC, USA?

Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS) 5 times a day. Alternatively, you can take a bus from Chicago Bus Station to Isle of Palms via Atlanta Bus Station and Charleston Bus Station in around 28h 49m.

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