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How to get fromChicago to Jeffersonvilleby bus (Greyhound, Flixbus), train, bus, car, plane, bus (Amtrak), or subway

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There are 8 ways to get from Chicago to Jeffersonville by bus (Greyhound, Flixbus), train, bus, car, plane, bus (Amtrak), or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    7h 34m
    $44–85

  2. Train, bus via Speedway

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis to El Mercadito Grocery - Clarksville, INbus bus Indianapolis
    9h 18m
    $99–189

  3. Drive  292.4 mi

    1. Drive from Chicago to Jeffersonvillecar car 292.4 mi
    5h 2m
    $54–78

  4. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Jeffersonvillecar car
    4h 37m
    $56–314

  5. Train, bus

    1. Take the train from Van Buren St. to Gary Metro Centertrain train Ssl / ...
    2. Take the bus from Gary Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    8h 35m
    $45–89

  6. Bus via Lafayette (Amtrak)

    1. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus Chicago
    2. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus Chicago
    9h 21m
    $56–100

  7. Subway to Chicago Midway International Airport, fly to Louisville International Airport, line 71 bus

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    3. Take the bus from Liberty @ 6th to Court @ Meigsbus bus
    5h 7m
    $90–611

  8. Fly Chicago O'Hare International Airport to Louisville International Airport, line 71 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    2. Take the bus from Liberty @ 6th to Court @ Meigsbus bus
    5h 37m
    $70–451

Chicago to Jeffersonville by bus and foot

Calendar40Weekly Services
Duration7h 34mAverage Duration
Ticket$44Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Jeffersonville.ExpandLaunch map view
  • Distance: 303.1 mi
  • Duration: 7h 34m

What companies run services between Chicago, IL, USA and Jeffersonville, IN, USA?

Greyhound USA operates a bus from Chicago Bus Station to Louisville Bus Station 4 times a day. Tickets cost $40–80 and the journey takes 6h 5m. Flixbus USA also services this route twice daily.

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