Rome2Rio

How to get fromChicago to Jeffersonvilleby bus (Greyhound, Amtrak), train, bus, car, plane, bus (Amtrak), or subway

Find Transport to Jeffersonville

See all options

There are 9 ways to get from Chicago to Jeffersonville by bus (Greyhound, Amtrak), train, bus, car, plane, bus (Amtrak), or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Indianapolis

    best
    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    6h 52m
    $55–95

  2. Bus (Amtrak)

    cheapest
    1. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    8h 5m
    $51–60

  3. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    8h 41m
    $131–214

  4. Drive  292.4 mi

    1. Drive from Chicago to Jeffersonvillecar car 292.4 mi
    5h 2m
    $54–78

  5. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Jeffersonvillecar car
    4h 29m
    $56–294

  6. Fly Chicago O'Hare International Airport to Covington, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Covington (CVG)plane plane ORD - CVG
    2. Drive from Covington (CVG) to Jeffersonvillecar car
    4h 45m
    $170–780

  7. Fly Chicago Midway International Airport to Covington, drive

    1. Fly from Chicago Midway International Airport (MDW) to Covington (CVG)plane plane MDW - CVG
    2. Drive from Covington (CVG) to Jeffersonvillecar car
    4h 23m
    $180–330

  8. Subway to Chicago Midway International Airport, fly to Louisville International Airport, line 71 bus

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    3. Take the bus from Liberty @ 6th to Court @ Meigsbus bus
    5h 7m
    $104–711

  9. Fly Chicago O'Hare International Airport to Louisville International Airport, line 71 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    2. Take the bus from Liberty @ 6th to Court @ Meigsbus bus
    5h 39m
    $74–481

Chicago to Jeffersonville by bus and foot

Calendar14Weekly Services
Duration6h 52mAverage Duration
Ticket$55Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Chicago to Jeffersonville.ExpandLaunch map view
  • Distance: 299 mi
  • Duration: 6h 52m

What companies run services between Chicago, IL, USA and Jeffersonville, IN, USA?

You can take a bus from Chicago Bus Station to Court @ Spring via Indianapolis Union Station, Louisville, KY, and Liberty @ Roy Wilkins in around 6h 52m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There