Rome2Rio

How to get fromChicago to Knoxvilleby plane, train, bus, bus (Flixbus), or car

Find Transport to Knoxville

See all options

There are 8 ways to get from Chicago to Knoxville by plane, train, bus, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3h 49m
    $158–675

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    5h 51m
    $84–380

  3. Train, bus

    1. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    33h 45m
    $498–884

  4. Bus

    1. Take the bus from Chicago Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    37h 45m
    $256–371

  5. Drive 525.7 mi

    1. Drive from Chicago to Knoxvillecar car 525.7 mi
    9h 10m
    $96–139

  6. Fly Chicago Midway International Airport to Mcghee Tyson Airport

    1. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    3h 21m
    $188–875

  7. Fly Chicago O'Hare International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 17m
    $130–683

  8. Train, bus via Ossining

    1. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    2. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    34h 22m
    $453–790

Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) flights

Calendar81Weekly Planes
Duration2h 18mAverage Duration
Ticket$108Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chicago to Knoxville.ExpandLaunch map view
  • Distance: 506 mi
  • Duration: 3h 49m

What companies run services between Chicago, IL, USA and Knoxville, TN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from Chicago Bus Station to Knoxville Station Hall of Fame via New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 37h 45m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

More Questions & Answers