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How to get fromChicago to Knoxville Airport (TYS)by plane, car, train, bus, bus (Flixbus), or bus (Greyhound)

Find Transport to Knoxville Airport (TYS)

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There are 8 ways to get from Chicago to Knoxville Airport (TYS) by plane, car, train, bus, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    3h 32m
    $102–605

  2. Fly Chicago O'Hare International Airport to Tri-Cities Regional Tn/Va Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ORD - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Knoxville-Airport-TYScar car
    5h 26m
    $98–475

  3. Fly Chicago O'Hare International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Chattanooga Metropolitan Airport (CHA)plane plane ORD - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxville-Airport-TYScar car
    5h 19m
    $130–683

  4. Train, bus

    1. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train Lake Shore Limited / ...
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    33h 58m
    $468–822

  5. Bus

    1. Take the bus from Chicago Bus Station to New York City Chinatownbus bus FlixBus N2640
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    34h 4m
    $319–450

  6. Fly Chicago Midway International Airport to Mcghee Tyson Airport

    1. Fly from Chicago Midway International Airport (MDW) to Mcghee Tyson Airport (TYS)plane plane MDW - TYS
    3h 2m
    $122–755

  7. Bus via Baltimore

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    35h 7m
    $348–599

  8. Drive 537.7 mi

    1. Drive from Chicago to Knoxville Airport (TYS)car car 537.7 mi
    9h 26m
    $99–142

Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) flights

Calendar72Weekly Planes
Duration2h 46mAverage Duration
Ticket$103Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Knoxville Airport (TYS).ExpandLaunch map view
  • Distance: 493.2 mi
  • Duration: 3h 32m

What companies run services between Chicago, IL, USA and Knoxville Airport (TYS), USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Chicago Bus Station to Knoxville Airport (TYS) via New York, NY and Knoxville, TN in around 34h 4m.

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