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How to get fromChicago to Knoxvilleby plane, taxi, train, bus, car, or bus (Greyhound)

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There are 6 ways to get from Chicago to Knoxville by plane, taxi, train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Des Moines, taxi

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    2. Take the taxi from Des-Moines-Airport-DSM to Knoxvilletaxi taxi
    4h 2m
    $158–595

  2. Drive 326.5 mi

    cheapest
    1. Drive from Chicago to Knoxvillecar car 326.5 mi
    5h 36m
    $60–87

  3. Train, bus

    1. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train Southwest Chief / ...
    2. Take the bus from Galesburg to Oskaloosabus bus Greyhound US0157S
    7h 46m
    $129–222

  4. Fly Chicago Midway International Airport to Des Moines, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    2. Take the taxi from Des-Moines-Airport-DSM to Knoxvilletaxi taxi
    3h 44m
    $178–755

  5. Fly Chicago O'Hare International Airport to Burlington Municipal Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane plane ORD - BRL
    2. Drive from Burlington Municipal Airport (BRL) to Knoxvillecar car
    5h 40m
    $80–170

  6. Bus (Greyhound)

    1. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    2. Take the bus from Des Moines to Monroebus bus Greyhound US0157S
    8h 33m
    $90–149

Chicago O'Hare International Airport (ORD) to Des Moines (DSM) flights

Calendar63Weekly Planes
Duration1h 30mAverage Duration
Ticket$77Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Knoxville.ExpandLaunch map view
  • Distance: 351.5 mi
  • Duration: 4h 2m

What companies run services between Chicago, IL, USA and Knoxville, IA, USA?

You can take a bus from Chicago Bus Station to Knoxville via Des Moines and Monroe in around 8h 33m.

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