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How to get fromChicago to La Jollaby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Find Transport to La Jolla

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There are 6 ways to get from Chicago to La Jolla by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    7h 6m
    $204–860

  2. Fly from Chicago O'Hare International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    7h 26m
    $154–660

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus bus
    3. Take the bus from Phoenix Bus Station to San Diego Greyhound Bus Stopbus bus
    46h 38m
    $347–657

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2. Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    46h 44m
    $758–1,523

  5. Drive 2,072.2 mi

    1. Drive from Chicago to La Jollacar car 2,072.2 mi
    32h 37m
    $379–547

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to San Diego International Airport (SAN)plane plane MKE - SAN
    8h 30m
    $262–1,025

Chicago to La Jolla by bus

Calendar7Weekly Buses
Duration46h 38mAverage Duration
Ticket$347Cheapest Price
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Questions & Answers

Map of how to get from Chicago to La Jolla.ExpandLaunch map view
  • Distance: 1,754.5 mi
  • Duration: 7h 6m

What companies run services between Chicago, IL, USA and La Jolla, San Diego County, CA, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a bus from Chicago Bus Station to Silverado St & Herschel Av via St Louis Bus Station, Phoenix Bus Station, San Diego Greyhound Bus Stop, and Old Town Transit Center in around 46h 38m.

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