Rome2Rio

How to get fromChicago to Lake Cityby plane, bus, bus (Greyhound, Flixbus), train, or car

Find Transport to Lake City

See all options

There are 9 ways to get from Chicago to Lake City by plane, bus, bus (Greyhound, Flixbus), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Jacksonville, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Jacksonville (JAX)plane plane MDW - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 22m
    $122–626

  2. Fly Chicago O'Hare International Airport to Gainesville Regional Airport, bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Gainesville Regional Airport (GNV)plane plane ORD - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 51m
    $98–442

  3. Bus

    1. Take the bus from Chicago Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    23h 35m
    $166–325

  4. Train, bus

    1. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus Greyhound US0760S
    37h 46m
    $523–1,048

  5. Drive 954.7 mi

    1. Drive from Chicago to Lake Citycar car 954.7 mi
    17h 13m
    $175–252

  6. Fly Chicago O'Hare International Airport to Jacksonville, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Jacksonville (JAX)plane plane ORD - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 46m
    $192–526

  7. Fly Chicago Midway International Airport to Gainesville Regional Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Gainesville Regional Airport (GNV)plane plane MDW - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 20m
    $122–572

  8. Fly Chicago Midway International Airport to Orlando, bus

    1. Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane plane MDW - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    10h 25m
    $230–549

  9. Fly Chicago Midway International Airport to Valdosta, bus

    1. Fly from Chicago Midway International Airport (MDW) to Valdosta (VLD)plane plane MDW - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    11h 18m
    $138–615

Chicago to Lake City by bus

Calendar7Weekly Buses
Duration23h 35mAverage Duration
Ticket$166Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chicago to Lake City.ExpandLaunch map view
  • Distance: 939.1 mi
  • Duration: 7h 22m

What companies run services between Chicago, IL, USA and Lake City, FL, USA?

You can take a bus from Chicago Bus Station to Lake City Bus Station via Nashville Bus Station and Tallahassee in around 23h 35m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers