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How to get fromChicago to Lewistonby plane, bus, train (Amtrak), bus (Greyhound), or car

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There are 10 ways to get from Chicago to Lewiston by plane, bus, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Buffalo Niagara International Airport, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    5h 29m
    $168–384

  2. Bus via Cleveland

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Chicago
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    14h
    $56–143

  3. Train

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    2. Take the train from Buffalo Depew Station to Niagara Falls Amtrak Stationtrain train Empire Service / ...
    12h 33m
    $204–528

  4. Bus

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Buffalobus bus
    3. Take the bus from Ellicott Street & MTC Static to Portage Road & Cedar Avenuebus bus 40 / ...
    13h 40m
    $84–161

  5. Drive 521.9 mi

    1. Drive from Chicago to Lewistoncar car 521.9 mi
    8h 46m
    $96–138

  6. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    2. Take the bus from Buffalo Niagara International Airport to Niagara Falls USAbus bus
    5h 55m
    $178–314

  7. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester Bus Stop to Niagara Falls USAbus bus
    7h 8m
    $166–803

  8. Fly Chicago O'Hare International Airport to Toronto Island Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Toronto Island Airport (YTZ)plane plane ORD - YTZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    8h 11m
    $192–1,363

  9. Fly Chicago O'Hare International Airport to Toronto Pearson International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Toronto Pearson International Airport (YYZ)plane plane ORD - YYZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    8h 35m
    $348–1,172

  10. Fly Chicago Midway International Airport to Toronto Island Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Toronto Island Airport (YTZ)plane plane MDW - YTZ
    2. Take the bus from Toronto Union Station to Niagara Falls, ONbus bus
    8h
    $152–493

Chicago to Lewiston by bus

Calendar7Weekly Buses
Duration14hAverage Duration
Ticket$56Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Lewiston.ExpandLaunch map view
  • Distance: 523.1 mi
  • Duration: 5h 29m

What companies run services between Chicago, IL, USA and Lewiston, NY, USA?

You can take a train from Chicago Union Station to Lewiston via Buffalo Depew Station and Niagara Falls Amtrak Station in around 12h 33m. Alternatively, you can take a bus from Chicago Bus Station to Lewiston Academy Park via Cleveland Bus Station, Buffalo, Ellicott Street & MTC Static, Portage Road & Cedar Avenue, and Oakwood Cemetery in around 13h 40m.

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