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How to get fromChicago to Lexingtonby plane, bus, bus (Amtrak, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

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There are 9 ways to get from Chicago to Lexington by plane, bus, bus (Amtrak, Greyhound), train (Amtrak), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Piedmont Triad International Airport, line 3 bus, bus

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane plane ORD - GSO
    2. Take the bus from Coble Transportation Center to High Point Terminalbus bus
    3. Take the bus from High Point Transportation Terminal to Lexington Davidson Co Trans Termbus bus
    6h 29m
    $124–632

  2. Bus via Columbus

    cheapest
    1. Take the bus from Chicago to Columbus - Mound Stbus bus Chicago
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus Greyhound US0140
    19h 38m
    $96–202

  3. Bus

    1. Take the bus from Chicago Union Station to Toledobus bus Amtrak Thruway Connecting Service
    2. Take the bus from Toledo Bus Stop to Winston Salem(Trans Center)bus bus Greyhound US0140
    19h 26m
    $167–285

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Carytrain train Floridian
    2. Take the train from Cary to High Pointtrain train Piedmont / ...
    28h 30m
    $378–774

  5. Drive 696 mi

    1. Drive from Chicago to Lexingtoncar car 696 mi
    13h 7m
    $127–184

  6. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the train from Charlotte Amtrak Station to High Pointtrain train
    8h 37m
    $152–480

  7. Fly Chicago Midway International Airport to Raleigh-Durham International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    2. Take the train from Durham Amtrak Station to High Pointtrain train
    8h 39m
    $182–365

  8. Fly Chicago O'Hare International Airport to Raleigh-Durham International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Raleigh-Durham International Airport (RDU)plane plane ORD - RDU
    2. Take the train from Durham Amtrak Station to High Pointtrain train
    9h 2m
    $202–815

  9. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the train from Charlotte Amtrak Station to High Pointtrain train
    8h 20m
    $152–770

Chicago to Lexington by bus

Calendar2Weekly Buses
Duration19h 26mAverage Duration
Ticket$167Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Lexington.ExpandLaunch map view
  • Distance: 640.7 mi
  • Duration: 6h 29m

What companies run services between Chicago, IL, USA and Lexington, NC, USA?

You can take a bus from Chicago Union Station to Lexington via Toledo Bus Stop and Winston-Salem in around 19h 26m. Alternatively, you can take a train from Chicago Union Station to Lexington Davidson Co Trans Term via Cary, High Point, and High Point Transportation Terminal in around 28h 30m.

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