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How to get fromChicago to Lexingtonby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak, Greyhound)

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There are 8 ways to get from Chicago to Lexington by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Columbia

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    4h 7m
    $200–940

  2. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Lexingtoncar car
    5h 39m
    $114–581

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Camdenbus bus
    3. Take the bus from Camden to Columbia, SCbus bus Nyc
    22h 15m
    $213–376

  4. Train, bus

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train Floridian
    2. Take the bus from S Saunders St at Chapanoke Rd - Raleigh to Columbia, SCbus bus Nyc
    30h 4m
    $420–799

  5. Drive 758.8 mi

    1. Drive from Chicago to Lexingtoncar car 758.8 mi
    14h 11m
    $139–200

  6. Fly Chicago Midway International Airport to Columbia

    1. Fly from Chicago Midway International Airport (MDW) to Columbia (CAE)plane plane MDW - CAE
    5h 48m
    $280–1,340

  7. Fly Chicago Midway International Airport to Charleston International Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    2. Drive from Charleston-Airport-CHS to Lexingtoncar car
    5h 35m
    $122–585

  8. Bus via Toledo

    1. Take the bus from Chicago Union Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Camdenbus bus
    4. Take the bus from Camden to Columbia, SCbus bus Nyc
    23h 48m
    $256–413

Chicago O'Hare International Airport (ORD) to Columbia (CAE) flights

Calendar99Weekly Planes
Duration3h 39mAverage Duration
Ticket$175Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Lexington.ExpandLaunch map view
  • Distance: 692.3 mi
  • Duration: 4h 7m

What companies run services between Chicago, IL, USA and Lexington, SC, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE) hourly. Alternatively, you can take a bus from Chicago Bus Station to Lexington via Atlanta, Camden, and Columbia, SC in around 22h 15m.

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