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How to get fromChicago to Louisvilleby bus (Greyhound, Amtrak), train, bus, car, subway, plane, or bus (Amtrak)

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There are 7 ways to get from Chicago to Louisville by bus (Greyhound, Amtrak), train, bus, car, subway, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Indianapolis

    best
    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    6h 30m
    $50–97

  2. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    8h 19m
    $87–172

  3. Drive 293.6 mi

    1. Drive from Chicago to Louisvillecar car 293.6 mi
    5h 4m
    $54–78

  4. Subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    3h 56m
    $78–558

  5. Bus (Amtrak)

    1. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    7h
    $50–60

  6. Fly Chicago O'Hare International Airport to Louisville International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    4h 24m
    $64–408

  7. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    4h 36m
    $110–674

Chicago to Louisville by bus

Calendar14Weekly Buses
Duration6h 30mAverage Duration
Ticket$50Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Louisville.ExpandLaunch map view
  • Distance: 294.8 mi
  • Duration: 6h 30m

What companies run services between Chicago, IL, USA and Louisville, KY, USA?

You can take a bus from Chicago Bus Station to Louisville, KY via Indianapolis Union Station in around 6h 30m. Alternatively, American Airlines and United Airlines fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF) every 2 hours.

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