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How to get fromChicago to Louisville, KYby bus (Greyhound, Flixbus), train, bus, car, subway, plane, or bus (Amtrak)

Find Transport to Louisville, KY

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There are 10 ways to get from Chicago to Louisville, KY by bus (Greyhound, Flixbus), train, bus, car, subway, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Chicago Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    6h 5m
    $40–75

  2. Train, bus via Indianapolis

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville Bus Stationbus bus Greyhound US0100 / ...
    7h 44m
    $72–156

  3. Drive  295.4 mi

    1. Drive from Chicago to Louisville, KYcar car 295.4 mi
    5h 5m
    $54–78

  4. Subway to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    4h 28m
    $94–658

  5. Train, bus

    1. Take the train from Van Buren St. to Gary Metro Centertrain train Ssl / ...
    2. Take the bus from Gary Bus Station to Louisville Bus Stationbus bus Greyhound US0100
    7h 6m
    $48–74

  6. Bus via Lafayette (Amtrak)

    1. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus Chicago
    2. Take the bus from Lafayette Amtrak Station to Louisville, KYbus bus Chicago
    7h 35m
    $54–94

  7. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Louisville, KYcar car
    4h 32m
    $56–305

  8. Fly Chicago O'Hare International Airport to Louisville International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    4h 54m
    $74–468

  9. Fly Chicago O'Hare International Airport to Covington, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Covington (CVG)plane plane ORD - CVG
    2. Take the bus from Cincinnati to Louisvillebus bus
    6h 47m
    $164–852

  10. Fly Chicago Midway International Airport to Covington, bus

    1. Fly from Chicago Midway International Airport (MDW) to Covington (CVG)plane plane MDW - CVG
    2. Take the bus from Cincinnati to Louisvillebus bus
    6h 32m
    $164–412

Chicago to Louisville, KY by bus

Calendar40Weekly Buses
Duration6h 5mAverage Duration
Ticket$40Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Louisville, KY.ExpandLaunch map view
  • Distance: 298.3 mi
  • Duration: 6h 5m

What companies run services between Chicago, IL, USA and Louisville, KY, USA?

Greyhound USA operates a bus from Chicago Bus Station to Louisville Bus Station 4 times a day. Tickets cost $45–75 and the journey takes 6h 5m. Flixbus USA also services this route twice daily. Alternatively, American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF) every 2 hours.

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