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How to get fromChicago to Louisvilleby train, bus, bus (Amtrak), car, plane, or bus (Flixbus)

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There are 10 ways to get from Chicago to Louisville by train, bus, bus (Amtrak), car, plane, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Chicago Union Station to Cleveland Amtraktrain train Floridian / ...
    2. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus 379 D / ...
    10h 17m
    $111–261

  2. Fly Chicago O'Hare International Airport to Akron, line 139 bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Akron (CAK)plane plane ORD - CAK
    2. Take the bus from Cornerstone Transit Center to E Main St And N Chapel Stbus bus
    6h 14m
    $40–237

  3. Bus via Toledo

    1. Take the bus from Chicago Union Station to Toledobus bus
    2. Take the bus from Toledo to Clevelandbus bus
    3. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus 380
    10h 36m
    $101–202

  4. Drive 374.6 mi

    1. Drive from Chicago to Louisvillecar car 374.6 mi
    7h 13m
    $69–99

  5. Train, bus via Toledo

    1. Take the train from Chicago Union Station to Toledotrain train
    2. Take the bus from Toledo to Clevelandbus bus
    3. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus 380
    10h 37m
    $89–237

  6. Train, bus via Toledo #2

    1. Take the train from Chicago Union Station to Toledotrain train
    2. Take the bus from Toledo Bus Stop to Robert K Pfaff Transit Center - Akronbus bus
    3. Take the bus from Robert K Pfaff Transit Center - Akron to Cornerstone Transit Centerbus bus 081
    10h 40m
    $97–227

  7. Bus

    1. Take the bus from Chicago Bus Station to Robert K Pfaff Transit Center - Akronbus bus FlixBus N2641
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Cornerstone Transit Centerbus bus 081
    10h 41m
    $63–132

  8. Fly Chicago Midway International Airport to Cleveland-Hopkins International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Cleveland-Hopkins International Airport (CLE)plane plane MDW - CLE
    2. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus
    7h 24m
    $90–553

  9. Fly Chicago O'Hare International Airport to Cleveland-Hopkins International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Cleveland-Hopkins International Airport (CLE)plane plane ORD - CLE
    2. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus
    7h 51m
    $376–853

  10. Fly Chicago Midway International Airport to John Glenn Columbus International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to John Glenn Columbus International Airport (CMH)plane plane MDW - CMH
    2. Take the bus from John Glenn Columbus Intnl Airport (CMH) to Canton Ohio Sarta Transit Stationbus bus
    8h 57m
    $130–617

Chicago to Louisville by bus

Calendar2Weekly Buses
Duration10h 36mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Louisville.ExpandLaunch map view
  • Distance: 411 mi
  • Duration: 10h 17m

What companies run services between Chicago, IL, USA and Louisville, Stark County, OH, USA?

You can take a bus from Chicago Union Station to E Main St And N Chapel St via Toledo, Cleveland Ohio Greyhound Station, and Cornerstone Transit Center in around 10h 36m.

Airlines
Train operators
Bus operators

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