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How to get fromChicago to Maconby train (Amtrak), car, plane, shuttle, or taxi

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There are 6 ways to get from Chicago to Macon by train (Amtrak), car, plane, shuttle, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    5h 16m
    $181–306

  2. Drive 360.9 mi

    cheapest
    1. Drive from Chicago to Maconcar car 360.9 mi
    6h 8m
    $66–96

  3. Fly to Columbia Regional Airport, shuttle

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU)plane plane ORD - COU
    2. Take a shuttle bus from Columbia to Maconshuttle bus
    5h 29m
    $100–375

  4. Fly to Kirksville Regional Airport, shuttle

    1. Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane plane ORD - IRK
    2. Take a shuttle bus from Hy-Vee - Kirksville to Maconshuttle bus
    4h 58m
    $104–244

  5. Fly to Burlington Municipal Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane plane ORD - BRL
    2. Drive from Burlington Municipal Airport (BRL) to Maconcar car
    5h 49m
    $84–175

  6. Fly to Quincy Regional Airport, taxi, shuttle

    1. Fly from Chicago O'Hare International Airport (ORD) to Quincy Regional Airport (UIN)plane plane ORD - UIN
    2. Take the taxi from Quincy Regional Airport (UIN) to Hannibaltaxi taxi
    3. Take a shuttle bus from Hannibal to Moberlyshuttle bus
    7h 11m
    $132–229

Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU) flights

Calendar42Weekly Planes
Duration1h 32mAverage Duration
Ticket$47Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Macon.ExpandLaunch map view
  • Distance: 318.2 mi
  • Duration: 5h 16m

What companies run services between Chicago, IL, USA and Macon, MO, USA?

Amtrak operates a train from Chicago Union Station to La Plata Station once daily. Tickets cost $95–200 and the journey takes 4h 52m.

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