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How to get fromChicago to Manchesterby plane, car, bus (Flixbus, Greyhound), bus (Amtrak, Greyhound), train, or bus

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There are 9 ways to get from Chicago to Manchester by plane, car, bus (Flixbus, Greyhound), bus (Amtrak, Greyhound), train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Manchestercar car
    5h 1m
    $60–301

  2. Bus

    1. Take the bus from Chicago Bus Station to Cincinnatibus bus FlixBus 2514 / ...
    2. Take the bus from Cincinnati Bus Station to Londonbus bus Greyhound US0110
    11h 59m
    $138–229

  3. Drive  449.7 mi

    1. Drive from Chicago to Manchestercar car 449.7 mi
    8h
    $80–115

  4. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Manchestercar car
    5h 56m
    $146–790

  5. Fly Chicago Midway International Airport to Louisville International Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    2. Drive from Louisville-Airport-SDF to Manchestercar car
    6h 8m
    $150–850

  6. Fly Chicago O'Hare International Airport to Louisville International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    2. Drive from Louisville-Airport-SDF to Manchestercar car
    6h 33m
    $106–540

  7. Fly Chicago O'Hare International Airport to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ORD - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Manchestercar car
    6h 54m
    $70–330

  8. Bus via Lafayette

    1. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus
    2. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis to Cincinnatibus bus
    4. Take the bus from Cincinnati Bus Station to Londonbus bus
    13h 34m
    $141–269

  9. Train, bus

    1. Take the train from Chicago Union Station to Indianapolistrain train
    2. Take the bus from Indianapolis to Cincinnatibus bus
    3. Take the bus from Cincinnati Bus Station to Londonbus bus
    13h 48m
    $211–346

Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX) flights

Calendar63Weekly Planes
Duration1h 35mAverage Duration
Ticket$41Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Manchester.ExpandLaunch map view
  • Distance: 441.4 mi
  • Duration: 5h 1m

What companies run services between Chicago, IL, USA and Manchester, KY, USA?

You can take a bus from Chicago Bus Station to Manchester via Cincinnati, Cincinnati, Cincinnati Bus Station, and London in around 11h 59m.

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