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How to get fromChicago to Mayo Clinicby plane, train, bus, car, or bus (Flixbus, Greyhound)

Find Transport to Mayo Clinic

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There are 8 ways to get from Chicago to Mayo Clinic by plane, train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Rochester

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 31m
    $38–305

  2. Train, bus via Milwaukee

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    8h 15m
    $117–172

  3. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    10h 2m
    $254–386

  4. Drive  347.1 mi

    1. Drive from Chicago to Mayo Cliniccar car 347.1 mi
    5h 41m
    $62–89

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 24m
    $272–855

  6. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 14m
    $142–655

  7. Bus

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 6m
    $76–129

  8. Bus via Chicago Bus Station

    1. Take the bus from Chicago Bus Station to Madisonbus bus FlixBus 2548 / ...
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 11m
    $78–122

Chicago to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration8h 15mAverage Duration
Ticket$117Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Mayo Clinic.ExpandLaunch map view
  • Distance: 294.8 mi
  • Duration: 4h 31m

What companies run services between Chicago, IL, USA and Mayo Clinic, MN, USA?

American Airlines flies from Chicago O'Hare International Airport (ORD) to Rochester (RST) 3 times a day. Alternatively, you can take a bus from W Jackson Blvd, after S Clinton St to Mayo Clinic via 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 9h 6m.

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