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How to get fromChicago to Mayo Clinicby plane, train, bus, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Chicago to Mayo Clinic by plane, train, bus, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Rochester

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 25m
    $48–335

  2. Train, bus via Milwaukee

    1. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    8h 17m
    $98–156

  3. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochester, MNbus bus Minneapolis / ...
    10h 9m
    $162–309

  4. Drive 347.1 mi

    1. Drive from Chicago to Mayo Cliniccar car 347.1 mi
    5h 44m
    $64–92

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 9m
    $274–457

  6. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 57m
    $130–537

  7. Bus

    1. Take the bus from Chicago Bus Station to Wisconsin Dellsbus bus Greyhound US0150
    2. Take the bus from Wisconsin Dells to Rochester, MNbus bus Milwaukee
    8h 43m
    $78–127

  8. Bus via Madison

    1. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson 966 / ...
    9h 18m
    $76–129

Chicago to Mayo Clinic by train, bus, and foot

Calendar14Weekly Services
Duration10h 9mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Mayo Clinic.ExpandLaunch map view
  • Distance: 294.8 mi
  • Duration: 4h 25m

What companies run services between Chicago, IL, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Chicago Bus Station to Mayo Clinic via Wisconsin Dells and Rochester in around 8h 43m.

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