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How to get fromChicago to Mechanicsburgby plane, bus, train (Amtrak), bus (Flixbus), car, taxi, or bus (Greyhound)

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There are 7 ways to get from Chicago to Mechanicsburg by plane, bus, train (Amtrak), bus (Flixbus), car, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport, bus

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT)plane plane ORD - MDT
    2. Take the bus from Market Square Transfer Center to E Main St & Arch St WBbus bus
    5h 30m
    $70–369

  2. Train (Amtrak)

    1. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train Floridian
    2. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train Pennsylvanian
    16h 54m
    $231–473

  3. Bus

    1. Take the bus from Chicago Bus Station to Harrisburg Bus Stationbus bus FlixBus N2640 / ...
    16h 59m
    $172–237

  4. Drive 648.9 mi

    1. Drive from Chicago to Mechanicsburgcar car 648.9 mi
    10h 43m
    $119–172

  5. Fly to Lancaster, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Lancaster (LNS)plane plane ORD - LNS
    2. Take the taxi from Lancaster-Airport-LNS to Mechanicsburgtaxi taxi
    4h 49m
    $198–535

  6. Fly to Penn State University Park Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Penn State University Park Airport (SCE)plane plane ORD - SCE
    2. Take the bus from State College Regional Airport to Harrisburg Bus Stationbus bus
    7h 28m
    $94–392

  7. Bus via Baltimore

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0164
    2. Take the bus from Baltimore Downtown Bus Station to Harrisburg Bus Stationbus bus Greyhound US0430
    21h 29m
    $150–270

Chicago to Mechanicsburg by train, foot, and bus (Amtrak)

Calendar7Weekly Services
Duration16h 54mAverage Duration
Ticket$231Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Mechanicsburg.ExpandLaunch map view
  • Distance: 629.9 mi
  • Duration: 5h 30m

What companies run services between Chicago, IL, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a train from Chicago Union Station to E Main St & Arch St WB via Pittsburgh Amtrak Station, Harrisburg, and Market Square Transfer Center in around 16h 54m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to Harrisburg Bus Station once daily. Tickets cost $120–210 and the journey takes 15h 55m. Jefferson Lines also services this route once daily.

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