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How to get fromChicago to Mendonby train (Amtrak), car, or plane

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There are 5 ways to get from Chicago to Mendon by train (Amtrak), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train Carl Sandburg / ...
    4h 39m
    $145–255
  2. Drive 270 mi

    cheapest
    1. Drive from Chicago to Mendoncar car 270 mi
    5h 40m
    $50–72
  3. Fly to Quincy Regional Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Quincy Regional Airport (UIN)plane plane ORD - UIN
    3h 27m
    $112–205
  4. Fly to Burlington Municipal Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Burlington Municipal Airport (BRL)plane plane ORD - BRL
    2. Drive from Burlington Municipal Airport (BRL) to Mendoncar car
    4h 35m
    $68–153
  5. Fly to Kirksville Regional Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Kirksville Regional Airport (IRK)plane plane ORD - IRK
    2. Drive from Kirksville Regional Airport (IRK) to Mendoncar car
    5h 25m
    $82–218

Chicago O'Hare International Airport (ORD) to Quincy Regional Airport (UIN) flights

Calendar7Weekly Planes
Duration1h 20mAverage Duration
Ticket$55Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Mendon, IL, USA?

Amtrak operates a train from Chicago Union Station to Quincy Amtrak Station twice daily. Tickets cost $100–200 and the journey takes 4h 22m. Alternatively, Corporate Flight Management Inc flies from Chicago O'Hare International Airport (ORD) to Quincy Regional Airport (UIN) once daily.

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