There are 6 ways to get from Chicago to Mesa by plane, train, bus, bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago Midway International Airport
best- Fly from Chicago Midway International Airport (MDW) to Phoenix (PHX)plane MDW - PHX
6h 7m$124–237Train, bus
- Take the train from Chicago Union Station to Flagstafftrain Southwest Chief
- Take the bus from Flagstaff Train Station to Tempebus FlixBus 2047
36h 5m$431–999Bus (Greyhound)
- Take the bus from Chicago Bus Station to Denver Union Stationbus
- Take the bus from Denver Union Station to El Paso Bus Stationbus
- Take the bus from El Paso Bus Station to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus
47h 48m$333–532Drive 1,688.8 mi
- Drive from Chicago to Mesacar 1,688.8 mi
29h 38m$309–446Fly from Chicago O'Hare International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX)plane ORD - PHX
6h 29m$194–377Train to General Mitchell International Airport, fly
- Take the train from Chicago Union Station to Milwaukeetrain
- Fly from General Mitchell International Airport (MKE) to Phoenix (PHX)plane MKE - PHX
7h 40m$275–615
Chicago to Mesa by train, bus, and tram
Comparing Your Travel Options
The cheapest way to get from Chicago to Mesa is to fly which costs $120 - $240 and takes 6h 7m.
The fastest way to get from Chicago to Mesa is to fly which takes 6h 7m and costs $120 - $240.
No, there is no direct bus from Chicago station to Mesa. However, there are services departing from Chicago Bus Station and arriving at University Dr & Mesa Dr via Denver Union Station, El Paso Bus Station and University Dr & Rural Rd. The journey, including transfers, takes approximately 47h 48m.
The distance between Chicago and Mesa is 1474 miles. The road distance is 1698.7 miles.
The best way to get from Chicago to Mesa without a car is to train and bus which takes 36h 5m and costs $430 - $1,000.
It takes approximately 6h 7m to get from Chicago to Mesa, including transfers.
Chicago to Mesa bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Chicago to Mesa is to fly which takes 6h 7m and costs $120 - $240. Alternatively, you can bus, which costs $330 - $550 and takes 47h 48m.
Chicago to Mesa bus services, operated by Greyhound USA, arrive at Denver Union Station.
Mesa is 2h behind Chicago. It is currently 9:08 PM in Chicago and 7:08 PM in Mesa.
What companies run services between Chicago, IL, USA and Mesa, AZ, USA?
Southwest Airlines flies from Chicago Midway International Airport (MDW) to Phoenix (PHX) every 3 hours. Alternatively, you can take a bus from Chicago Bus Station to University Dr & Mesa Dr via Denver Union Station, El Paso Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, 44th St/Washington, University Dr/Rural Rd, and University Dr & Rural Rd in around 47h 48m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Phoenix
- Ave. Duration
- 3h 41m
- When
- Every day
- Estimated price
- $130–650
Flights from Chicago Midway International Airport to Phoenix via Kansas City
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $130–650
Flights from Chicago Midway International Airport to Phoenix via Omaha
- Ave. Duration
- 5h 30m
- When
- Monday, Thursday, and Friday
- Estimated price
- $130–650
Flights from General Mitchell International Airport to Phoenix
- Ave. Duration
- 3h 42m
- When
- Every day
- Estimated price
- $150–700
Flights from General Mitchell International Airport to Phoenix via Chicago Midway International Airport
- Ave. Duration
- 5h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $150–700
Flights from General Mitchell International Airport to Phoenix via St. Louis
- Ave. Duration
- 5h 20m
- When
- Saturday
- Estimated price
- $160–750
Flights from General Mitchell International Airport to Phoenix via Denver
- Ave. Duration
- 5h 35m
- When
- Monday to Wednesday
- Estimated price
- $150–700
Flights from General Mitchell International Airport to Phoenix via Kansas City
- Ave. Duration
- 5h 35m
- When
- Tuesday and Wednesday
- Estimated price
- $150–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Flagstaff
- Ave. Duration
- 31h 44m
- Frequency
- Once daily
- Estimated price
- $400–1,000
- Website
- Amtrak
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $20–50
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Flagstaff Train Station to Tempe
- Ave. Duration
- 2h 50m
- Frequency
- 5 times a week
- Estimated price
- $22–35
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Yes, the driving distance between Chicago to Mesa is 1699 miles. It takes approximately 29h 38m to drive from Chicago to Mesa.
Book your Chicago to Mesa bus tickets online with Omio.
There are 2791+ hotels available in Mesa.







