There are 5 ways to get from Chicago to Mississippi by plane, bus (Greyhound, Flixbus), train (Amtrak), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago O'Hare International Airport
best- Fly from Chicago O'Hare International Airport (ORD) to Memphis (MEM)plane ORD - MEM
3h 46m$120–632Bus
cheapest- Take the bus from Chicago Bus Station to Memphis Bus Stationbus Greyhound US0125
- Take the bus from Memphis Bus Station to Jacksonbus Greyhound US1173
14h 15m$113–221Train (Amtrak)
- Take the train from Chicago Union Station to Jacksontrain City of New Orleans
15h 35m$240–490Drive 739.2 mi
- Drive from Chicago to Jacksoncar 739.2 mi
11h 59m$135–195Fly from Chicago Midway International Airport
- Fly from Chicago Midway International Airport (MDW) to Memphis (MEM)plane MDW - MEM
3h 20m$144–782
Chicago to Mississippi by bus
Questions & Answers
The cheapest way to get from Chicago to Mississippi is to bus which costs $110 - $230 and takes 14h 15m.
The fastest way to get from Chicago to Mississippi is to fly which takes 3h 20m and costs $140 - $800.
No, there is no direct bus from Chicago station to Mississippi. However, there are services departing from Chicago Bus Station and arriving at Jackson via Memphis Bus Station. The journey, including transfers, takes approximately 14h 15m.
Yes, there is a direct train departing from Chicago Union Station station and arriving at Jackson. Services depart once daily, and operate every day. The journey takes approximately 15h 35m.
The distance between Chicago and Mississippi is 520 miles. The road distance is 743.5 miles.
The best way to get from Chicago to Mississippi without a car is to bus which takes 14h 15m and costs $110 - $230.
It takes approximately 3h 46m to get from Chicago to Mississippi, including transfers.
Chicago to Mississippi bus services, operated by Greyhound USA, depart from Chicago Bus Station.
Chicago to Mississippi train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago to Mississippi is to fly which takes 3h 46m and costs $120 - $650. Alternatively, you can bus, which costs $110 - $230 and takes 14h 15m, you could also train, which costs $240 - $490 and takes 15h 35m.
What companies run services between Chicago, IL, USA and Mississippi, USA?
American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Memphis (MEM) every 2 hours. Alternatively, you can take a bus from Chicago Bus Station to Jackson via Memphis Bus Station in around 14h 15m.
- Website
- united.com
Flights from Chicago O'Hare International Airport to Memphis
- Ave. Duration
- 2h 3m
- When
- Every day
- Estimated price
- $95–600
- Website
- southwest.com
Flights from Chicago Midway International Airport to Memphis
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $120–750
Flights from Chicago Midway International Airport to Memphis via Nashville
- Ave. Duration
- 3h 45m
- When
- Monday, Thursday, and Friday
- Estimated price
- $140–800
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Memphis
- Ave. Duration
- 1h 53m
- When
- Every day
- Estimated price
- $95–600
- Website
- delta.com
Flights from Chicago O'Hare International Airport to Memphis via Atlanta
- Ave. Duration
- 4h 13m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–750
Flights from Chicago O'Hare International Airport to Memphis via Detroit
- Ave. Duration
- 4h 30m
- When
- Saturday
- Estimated price
- $140–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Jackson
- Ave. Duration
- 15h 35m
- Frequency
- Once daily
- Estimated price
- $240–490
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Chicago Bus Station to Memphis Bus Station
- Ave. Duration
- 9h 20m
- Frequency
- Once daily
- Estimated price
- $80–160
- Website
- https://www.greyhound.com/
Bus from Memphis Bus Station to Jackson
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Chicago Bus Station to Memphis Bus Station
- Ave. Duration
- 11h
- Frequency
- Once daily
- Estimated price
- $80–140
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Chicago to Mississippi bus services, operated by Greyhound USA, arrive at Memphis Bus Station.
Chicago to Mississippi train services, operated by Amtrak, arrive at Jackson station.
Yes, the driving distance between Chicago to Mississippi is 744 miles. It takes approximately 11h 59m to drive from Chicago to Mississippi.
Book your Chicago to Mississippi train tickets online with Omio.
Book your Chicago to Mississippi bus tickets online with Omio and FlixBus.
There are 211+ hotels available in Mississippi.






