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How to get fromChicago to Mount Pleasantby plane, car, train (Amtrak), subway, or bus

Find Transport to Mount Pleasant

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There are 7 ways to get from Chicago to Mount Pleasant by plane, car, train (Amtrak), subway, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Columbia, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Drive from Columbia-Airport-CAE to Mount Pleasantcar car
    5h 48m
    $76–354

  2. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 43m
    $738–1,124

  3. Drive  875.2 mi

    1. Drive from Chicago to Mount Pleasantcar car 875.2 mi
    16h 3m
    $150–217

  4. Subway to Chicago Midway International Airport, fly to Charleston International Airport, line 41 bus

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    3. Take the bus from Mary St / Meeting St to Coleman Blvd / Chuck Dawley Blvdbus bus
    6h 36m
    $126–709

  5. Fly Chicago O'Hare International Airport to Charleston International Airport, line 41 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    2. Take the bus from Mary St / Meeting St to Coleman Blvd / Chuck Dawley Blvdbus bus
    6h 58m
    $506–859

  6. Fly Chicago O'Hare International Airport to Hilton Head Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Hilton Head Airport (HHH)plane plane ORD - HHH
    2. Drive from Hilton Head Airport (HHH) to Mount Pleasantcar car
    6h 28m
    $80–362

  7. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Drive from Charlotte-Airport-CLT to Mount Pleasantcar car
    7h 10m
    $168–860

Chicago O'Hare International Airport (ORD) to Columbia (CAE) flights

Calendar81Weekly Planes
Duration3h 43mAverage Duration
Ticket$57Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Mount Pleasant.ExpandLaunch map view
  • Distance: 798.4 mi
  • Duration: 5h 48m

What companies run services between Chicago, IL, USA and Mount Pleasant, SC, USA?

You can take a train from Chicago Union Station to Mount Pleasant via Petersburg Amtrak Station and Charleston Amtrak Station in around 28h 43m.

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