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How to get fromChicago to North Charlestonby plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

Find Transport to North Charleston

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There are 10 ways to get from Chicago to North Charleston by plane, bus (Greyhound, Flixbus), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Charleston International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    4h 41m
    $114–657

  2. Fly Chicago O'Hare International Airport to Columbia, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Drive from Columbia-Airport-CAE to North Charlestoncar car
    5h 36m
    $76–352

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    28h 25m
    $201–325

  4. Train via Petersburg (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 26m
    $699–1,076

  5. Drive  865.7 mi

    1. Drive from Chicago to North Charlestoncar car 865.7 mi
    15h 52m
    $153–221

  6. Fly Chicago O'Hare International Airport to Charleston International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    5h 3m
    $504–857

  7. Fly Chicago O'Hare International Airport to Myrtle Beach, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Myrtle Beach (MYR)plane plane ORD - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    7h 29m
    $86–346

  8. Fly Chicago O'Hare International Airport to Savannah, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Savannah (SAV)plane plane ORD - SAV
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    6h 57m
    $198–695

  9. Fly Chicago Midway International Airport to Savannah, train

    1. Fly from Chicago Midway International Airport (MDW) to Savannah (SAV)plane plane MDW - SAV
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    6h 33m
    $258–1,045

  10. Train (Amtrak)

    1. Take the train from Chicago Union Station to Savannah Stationtrain train Floridian
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train Palmetto / ...
    34h 11m
    $832–1,282

Chicago to North Charleston by bus

Calendar7Weekly Buses
Duration28h 25mAverage Duration
Ticket$201Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to North Charleston.ExpandLaunch map view
  • Distance: 764.4 mi
  • Duration: 4h 41m

What companies run services between Chicago, IL, USA and North Charleston, SC, USA?

Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS) 4 times a day. Alternatively, you can take a bus from Chicago Bus Station to Charleston Bus Station via Atlanta Bus Station in around 28h 25m.

Airlines
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Need to know: Greyhound

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