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How to get fromChicago to North Charlestonby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

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There are 9 ways to get from Chicago to North Charleston by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Charleston International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    4h 42m
    $104–557

  2. Fly Chicago O'Hare International Airport to Charleston International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    5h 9m
    $90–427

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus Greyhound US0641S
    28h 25m
    $191–370

  4. Train via Petersburg (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 26m
    $406–833

  5. Drive 865.7 mi

    1. Drive from Chicago to North Charlestoncar car 865.7 mi
    15h 52m
    $158–229

  6. Fly Chicago Midway International Airport to Savannah, train

    1. Fly from Chicago Midway International Airport (MDW) to Savannah (SAV)plane plane MDW - SAV
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    6h 33m
    $202–825

  7. Fly Chicago O'Hare International Airport to Savannah, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Savannah (SAV)plane plane ORD - SAV
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train
    6h 54m
    $172–675

  8. Fly Chicago Midway International Airport to Myrtle Beach, bus

    1. Fly from Chicago Midway International Airport (MDW) to Myrtle Beach (MYR)plane plane MDW - MYR
    2. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    7h 1m
    $114–479

  9. Train (Amtrak)

    1. Take the train from Chicago Union Station to Savannah Stationtrain train Floridian
    2. Take the train from Savannah Station to Charleston Amtrak Stationtrain train Palmetto / ...
    34h 11m
    $490–993

Chicago to North Charleston by bus

Calendar7Weekly Buses
Duration28h 25mAverage Duration
Ticket$191Cheapest Price
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Questions & Answers

Map of how to get from Chicago to North Charleston.ExpandLaunch map view
  • Distance: 764.4 mi
  • Duration: 4h 42m

What companies run services between Chicago, IL, USA and North Charleston, SC, USA?

Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS) 5 times a day. Alternatively, you can take a bus from Chicago Bus Station to Charleston Bus Station via Atlanta Bus Station in around 28h 25m.

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