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How to get fromChicago to Orangeburgby plane, taxi, bus (Amtrak, Greyhound, Flixbus), train (Amtrak), or car

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There are 6 ways to get from Chicago to Orangeburg by plane, taxi, bus (Amtrak, Greyhound, Flixbus), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Columbia, taxi

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi taxi
    4h 29m
    $182–495

  2. Fly Chicago Midway International Airport to Charleston International Airport, drive

    cheapest
    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    2. Drive from Charleston-Airport-CHS to Orangeburgcar car
    4h 51m
    $124–624

  3. Bus

    1. Take the bus from Chicago Union Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    23h 11m

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Denmark Amtrak Stationtrain train Floridian
    30h 22m
    $797–1,203

  5. Drive  800.1 mi

    1. Drive from Chicago to Orangeburgcar car 800.1 mi
    14h 47m
    $146–211

  6. Fly Chicago O'Hare International Airport to Charleston International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    2. Drive from Charleston-Airport-CHS to Orangeburgcar car
    5h 14m
    $564–824

Chicago O'Hare International Airport (ORD) to Columbia (CAE) flights

Calendar88Weekly Planes
Duration3h 40mAverage Duration
Ticket$60Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Orangeburg.ExpandLaunch map view
  • Distance: 723.2 mi
  • Duration: 4h 29m

What companies run services between Chicago, IL, USA and Orangeburg, SC, USA?

You can take a bus from Chicago Union Station to Orangeburg via Toledo Bus Stop, Charlotte Bus Station, and Orangeburg in around 23h 11m. Alternatively, Amtrak operates a train from Chicago Union Station to Denmark Amtrak Station once daily. Tickets cost $700–1,200 and the journey takes 29h 50m.

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