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How to get fromChicago to Panama City Beachby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

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There are 11 ways to get from Chicago to Panama City Beach by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Northwest Florida Beaches International Airport (ECP)plane plane MDW - ECP
    4h 13m
    $152–670

  2. Fly Chicago O'Hare International Airport to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Destin–Fort Walton Beach Airport (VPS)plane plane ORD - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 32m
    $72–350

  3. Bus

    1. Take the bus from Chicago Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    23h 19m
    $189–298

  4. Train, bus via New Orleans

    1. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train
    2. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    3. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    27h 46m
    $575–888

  5. Drive  888.7 mi

    1. Drive from Chicago to Panama City Beachcar car 888.7 mi
    16h 47m
    $152–220

  6. Fly Chicago O'Hare International Airport to Northwest Florida Beaches International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Northwest Florida Beaches International Airport (ECP)plane plane ORD - ECP
    4h 38m
    $112–410

  7. Fly Chicago Midway International Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Destin–Fort Walton Beach Airport (VPS)plane plane MDW - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 7m
    $112–570

  8. Fly Chicago Midway International Airport to Pensacola International Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Pensacola International Airport (PNS)plane plane MDW - PNS
    2. Drive from Pensacola-Airport-PNS to Panama City Beachcar car
    6h 11m
    $108–520

  9. Fly Chicago O'Hare International Airport to Pensacola International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Pensacola International Airport (PNS)plane plane ORD - PNS
    2. Drive from Pensacola-Airport-PNS to Panama City Beachcar car
    6h 34m
    $74–320

  10. Bus via Atlanta

    1. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    2. Take the bus from Bloomington to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    26h 59m
    $190–311

  11. Train, bus

    1. Take the train from Chicago Union Station to Jacksonvilletrain train Floridian
    2. Take the bus from Jacksonville to Panama City Beach Bus Stationbus bus Greyhound US0760S
    43h 51m
    $916–1,411

Chicago Midway International Airport (MDW) to Northwest Florida Beaches International Airport (ECP) flights

Calendar21Weekly Planes
Duration4h 12mAverage Duration
Ticket$106Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Panama City Beach.ExpandLaunch map view
  • Distance: 827.2 mi
  • Duration: 4h 13m

What companies run services between Chicago, IL, USA and Panama City Beach, FL, USA?

Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Northwest Florida Beaches International Airport (ECP) 3 times a day. Alternatively, you can take a bus from Chicago Bus Station to Panama City Beach via Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 23h 19m.

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Need to know: Greyhound

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