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How to get fromChicago to Port Saint Lucieby plane, bus, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

Find Transport to Port Saint Lucie

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There are 9 ways to get from Chicago to Port Saint Lucie by plane, bus, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Orlando, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane plane MDW - MCO
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    8h 35m
    $216–459

  2. Fly Chicago O'Hare International Airport to Orlando, bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Orlando (MCO)plane plane ORD - MCO
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    8h 55m
    $106–449

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Port St Luciebus bus FlixBus N2401
    29h 24m
    $196–327

  4. Train, bus

    1. Take the train from Chicago Union Station to Kissimmee Amtrak Stationtrain train Floridian
    2. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus Orlando to Miami
    42h 39m
    $986–1,505

  5. Drive  1,219.7 mi

    1. Drive from Chicago to Port Saint Luciecar car 1,219.7 mi
    21h 29m
    $223–322

  6. Fly Chicago Midway International Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MDW - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    8h 11m
    $182–420

  7. Fly Chicago O'Hare International Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane ORD - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    8h 35m
    $192–460

  8. Fly Chicago Midway International Airport to Tampa, train, bus

    1. Fly from Chicago Midway International Airport (MDW) to Tampa (TPA)plane plane MDW - TPA
    2. Take the train from Tampa to Kissimmee Amtrak Stationtrain train
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    11h 25m
    $180–518

  9. Bus via Fort Pierce (Greyhound)

    1. Take the bus from Chicago Train Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Fort Piercebus bus Greyhound US0630
    33h 9m
    $224–341

Chicago to Port Saint Lucie by bus

Calendar7Weekly Buses
Duration29h 24mAverage Duration
Ticket$196Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,126.9 mi
  • Duration: 8h 35m

What companies run services between Chicago, IL, USA and Port Saint Lucie, FL, USA?

You can take a bus from Chicago Bus Station to SW PSL Blvd & SE Bayshore Blvd via Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St in around 29h 24m.

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