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How to get fromChicago to Port Saint Lucieby plane, bus, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

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There are 9 ways to get from Chicago to Port Saint Lucie by plane, bus, bus (Greyhound, Flixbus), train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Orlando, bus

    best
    1. Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane plane MDW - MCO
    2. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    7h 20m
    $232–552

  2. Fly Chicago O'Hare International Airport to Orlando, bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Orlando (MCO)plane plane ORD - MCO
    2. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    7h 45m
    $102–662

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus FlixBus 2512 / ...
    2. Take the bus from Atlanta Bus Station to Port St Luciebus bus FlixBus N2401
    27h 44m
    $205–366

  4. Train, bus

    1. Take the train from Chicago Union Station to Kissimmee Amtrak Stationtrain train Floridian
    2. Take the bus from Kissimmee to Fort Piercebus bus Tallahassee–Miami via Orlando
    42h 43m
    $593–1,165

  5. Drive 1,221.2 mi

    1. Drive from Chicago to Port Saint Luciecar car 1,221.2 mi
    21h 29m
    $223–322

  6. Fly Chicago Midway International Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MDW - FLL
    2. Take the bus from Fort Lauderdale Airport to Fort Piercebus bus
    7h 10m
    $156–700

  7. Fly Chicago O'Hare International Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane ORD - FLL
    2. Take the bus from Fort Lauderdale Airport to Fort Piercebus bus
    7h 36m
    $236–650

  8. Fly Chicago O'Hare International Airport to President Donald J. Trump International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to President Donald J. Trump International Airport (PBI)plane plane ORD - PBI
    2. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    9h 7m
    $132–572

  9. Bus via Fort Pierce

    1. Take the bus from Chicago Train Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Fort Piercebus bus Greyhound US0630
    33h 19m
    $201–389

Chicago to Port Saint Lucie by bus

Calendar7Weekly Buses
Duration27h 44mAverage Duration
Ticket$205Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,121.2 mi
  • Duration: 7h 20m

What companies run services between Chicago, IL, USA and Port Saint Lucie, FL, USA?

You can take a bus from Chicago Bus Station to SW PSL Blvd & SE Bayshore Blvd via Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St in around 27h 44m.

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