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How to get fromChicago to Saint Charlesby train (Amtrak), bus (Flixbus), car, plane, bus, subway, or train

Find Transport to Saint Charles

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There are 6 ways to get from Chicago to Saint Charles by train (Amtrak), bus (Flixbus), car, plane, bus, subway, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 11m
    $97–189

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    7h 53m
    $52–83

  3. Drive 309.5 mi

    1. Drive from Chicago to Saint Charlescar car 309.5 mi
    5h 15m
    $57–82

  4. Fly from Chicago O'Hare International Airport, line 34 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    4h 7m
    $276–709

  5. Subway to Chicago Midway International Airport, fly, line 34 bus

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    3. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    3h 52m
    $86–559

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 25m
    $514–924

Chicago to Saint Charles by train and bus (Amtrak)

Calendar38Weekly Services
Duration6h 11mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Saint Charles.ExpandLaunch map view
  • Distance: 302.1 mi
  • Duration: 6h 11m

What companies run services between Chicago, IL, USA and Saint Charles, MO, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $90–190 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station twice daily. Tickets cost $50–85 and the journey takes 5h 55m.

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