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How to get fromChicago to Saint Clairby train (Amtrak), bus (Flixbus, Greyhound), car, plane, train, or taxi

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There are 8 ways to get from Chicago to Saint Clair by train (Amtrak), bus (Flixbus, Greyhound), car, plane, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to Washington Stationtrain train Lincoln Service Missouri River Runner
    6h 50m
    $143–267

  2. Drive 347.6 mi

    cheapest
    1. Drive from Chicago to Saint Claircar car 347.6 mi
    5h 52m
    $64–92

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    2. Take the bus from St Louis Bus Station to Washingtonbus bus Greyhound US0175s
    8h 20m
    $91–145

  4. Fly Chicago O'Hare International Airport to Columbia Regional Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU)plane plane ORD - COU
    2. Drive from Columbia Regional Airport (COU) to Saint Claircar car
    5h 28m
    $66–333

  5. Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport, train, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the train from St. Louis to Washington Stationtrain train
    3. Take the taxi from Washington Station to Saint Clairtaxi taxi
    6h 12m
    $370–793

  6. Fly Chicago Midway International Airport to Lambert–St. Louis International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    2. Take the train from St. Louis to Washington Stationtrain train
    5h 56m
    $130–593

  7. Fly Chicago O'Hare International Airport to Abraham Lincoln Capital Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Abraham Lincoln Capital Airport (SPI)plane plane ORD - SPI
    2. Take the train from Springfield to Washington Stationtrain train
    7h 45m
    $136–441

  8. Train to General Mitchell International Airport, fly to Lambert–St. Louis International Airport, train

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    3. Take the train from St. Louis to Washington Stationtrain train
    7h 30m
    $566–1,007

Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU) flights

Calendar42Weekly Planes
Duration1h 32mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Saint Clair.ExpandLaunch map view
  • Distance: 347.8 mi
  • Duration: 6h 50m

What companies run services between Chicago, IL, USA and Saint Clair, MO, USA?

Amtrak operates a train from Chicago Union Station to Washington Station once daily. Tickets cost $100–220 and the journey takes 6h 27m. Alternatively, you can take a bus from Chicago Bus Station to Saint Clair via St Louis Bus Station and Washington in around 8h 20m.

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