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How to get fromChicago to Saint Louisby train, bus, bus (Amtrak), car, plane, taxi, or bus (Greyhound)

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There are 7 ways to get from Chicago to Saint Louis by train, bus, bus (Amtrak), car, plane, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Chicago Union Station to East Lansing Amtrak Stationtrain train Blue Water
    2. Take the bus from East Lansing, MI to Alma, MIbus bus 1488
    6h 30m
    $87–175

  2. Drive 256.1 mi

    cheapest
    1. Drive from Chicago to Saint Louiscar car 256.1 mi
    4h 26m
    $47–68

  3. Bus via Lansing

    1. Take the bus from Chicago Union Station to East Lansing Amtrak Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from East Lansing, MI to Alma, MIbus bus 1488
    6h 35m
    $97–145

  4. Fly to Mbs International Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Mbs International Airport (MBS)plane plane ORD - MBS
    2. Take the taxi from Mbs International Airport (MBS) to Saint Louistaxi taxi
    4h 3m
    $88–340

  5. Bus

    1. Take the bus from Chicago Bus Station to Jackson Bus Stopbus bus Greyhound US0160
    2. Take the bus from Jackson Transportation to Alma, MIbus bus 1488
    8h 45m
    $59–109

  6. Fly to Bishop International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Bishop International Airport (FNT)plane plane ORD - FNT
    2. Drive from Bishop International Airport (FNT) to Saint Louiscar car
    4h 28m
    $54–304

  7. Fly to Capital Region International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Capital Region International Airport (LAN)plane plane ORD - LAN
    2. Take the bus from Lansing, MI to Alma, MIbus bus
    5h 43m
    $90–515

Chicago O'Hare International Airport (ORD) to Mbs International Airport (MBS) flights

Calendar21Weekly Planes
Duration2h 2mAverage Duration
Ticket$41Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Saint Louis.ExpandLaunch map view
  • Distance: 263.6 mi
  • Duration: 6h 30m

What companies run services between Chicago, IL, USA and Saint Louis, MI, USA?

You can take a bus from Chicago Union Station to Saint Louis via East Lansing Amtrak Station, East Lansing, MI, and Alma, MI in around 6h 35m.

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