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How to get fromChicago to San Ysidroby plane, bus (Flixbus, Greyhound), train, bus, or car

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There are 8 ways to get from Chicago to San Ysidro by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to San Diego International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    7h 25m
    $206–875

  2. Fly Chicago O'Hare International Airport to San Diego International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    7h 45m
    $156–675

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus bus
    3. Take the bus from Phoenix Bus Station to San Ysidro Bus Terminalbus bus
    46h 33m
    $353–667

  4. Train, bus

    1. Take the train from Chicago Union Station to San Bernardinotrain train Southwest Chief
    2. Take the bus from San Bernardino Downtown Transit Center to San Ysidro Bus Terminalbus bus FlixBus 2015 / ...
    46h 41m
    $732–1,460

  5. Drive 2,087 mi

    1. Drive from Chicago to San Ysidrocar car 2,087 mi
    32h 47m
    $381–551

  6. Train to General Mitchell International Airport, fly to San Diego International Airport

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to San Diego International Airport (SAN)plane plane MKE - SAN
    8h 49m
    $264–1,040

  7. Fly Chicago Midway International Airport to Los Angeles International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Los Angeles International Airport (LAX)plane plane MDW - LAX
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus
    10h 27m
    $190–828

  8. Fly Chicago O'Hare International Airport to Los Angeles International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Los Angeles International Airport (LAX)plane plane ORD - LAX
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus
    10h 42m
    $240–508

Chicago to San Ysidro by bus

Calendar7Weekly Buses
Duration46h 33mAverage Duration
Ticket$353Cheapest Price
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Questions & Answers

Map of how to get from Chicago to San Ysidro.ExpandLaunch map view
  • Distance: 1,754.5 mi
  • Duration: 7h 25m

What companies run services between Chicago, IL, USA and San Ysidro, CA, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a bus from Chicago Bus Station to San Ysidro Bl & I-805 via St Louis Bus Station, Phoenix Bus Station, and San Ysidro Transit Center in around 46h 33m.

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