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How to get fromChicago to Sanfordby plane, train, bus (Greyhound, Flixbus), train (Amtrak), or car

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There are 7 ways to get from Chicago to Sanford by plane, train, bus (Greyhound, Flixbus), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Orlando, train

    best
    1. Fly from Chicago Midway International Airport (MDW) to Orlando (MCO)plane plane MDW - MCO
    2. Take the train from Sand Lake Road to Sanfordtrain train
    6h 16m
    $208–502
  2. Fly Chicago O'Hare International Airport to Orlando, train

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Orlando (MCO)plane plane ORD - MCO
    2. Take the train from Sand Lake Road to Sanfordtrain train
    6h 41m
    $78–612
  3. Bus

    1. Take the bus from Chicago Bus Station to Washington Union Stationbus bus Greyhound US0164
    2. Take the bus from Washington Union Station to Deltonabus bus FlixBus N2473
    34h 5m
    $252–441
  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Delandtrain train Floridian
    38h 29m
    $534–1,100
  5. Drive 1,101.7 mi

    1. Drive from Chicago to Sanfordcar car 1,101.7 mi
    20h 4m
    $202–291
  6. Train to South Bend, fly to Orlando Sanford

    1. Take the train from Van Buren St. to South Bend Airporttrain train
    2. Fly from South Bend (SBN) to Orlando Sanford (SFB)plane plane SBN - SFB
    5h 30m
    $113–514
  7. Train to General Mitchell International Airport, fly to Orlando, train

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Orlando (MCO)plane plane MKE - MCO
    3. Take the train from Sand Lake Road to Sanfordtrain train
    7h 54m
    $324–1,177

Chicago to Sanford by train (Amtrak)

Calendar7Weekly Trains
Duration38h 29mAverage Duration
Ticket$534Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Sanford, FL, USA?

You can take a bus from Chicago Bus Station to Sanford via Washington Union Station and Deltona in around 34h 5m. Alternatively, Amtrak operates a train from Chicago Union Station to Deland once daily. Tickets cost $500–1,100 and the journey takes 37h 13m.

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