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How to get fromChicago to Santeeby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Find Transport to Santee

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There are 6 ways to get from Chicago to Santee by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    7h 47m
    $168–740

  2. Fly from Chicago O'Hare International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    8h 5m
    $108–490

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus bus
    3. Take the bus from Phoenix Bus Station to El Cajon Transit Centerbus bus
    45h 25m
    $381–579

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2. Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    46h 59m
    $1,268–1,977

  5. Drive  2,074.7 mi

    1. Drive from Chicago to Santeecar car 2,074.7 mi
    32h 36m
    $379–547

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to San Diego International Airport (SAN)plane plane MKE - SAN
    9h 16m
    $225–871

Chicago to Santee by bus and tram

Calendar7Weekly Services
Duration45h 25mAverage Duration
Ticket$381Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Chicago to Santee.ExpandLaunch map view
  • Distance: 1,764.8 mi
  • Duration: 7h 47m

What companies run services between Chicago, IL, USA and Santee, CA, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN) every 3 hours. Alternatively, you can take a bus from Chicago Bus Station to Gillespie Field Station via St Louis Bus Station, Phoenix Bus Station, El Cajon Transit Center, and El Cajon Station in around 45h 25m.

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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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Need to know: Greyhound

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