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How to get fromChicago to Santiagoby plane, bus, car, train, or shuttle

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There are 9 ways to get from Chicago to Santiago by plane, bus, car, train, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Tocumen International Airport, bus

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Tocumen International Airport (PTY)plane plane ORD - PTY
    2. Take the bus from Paraíso, Panamá Province to Santiagobus bus
    13h 48m
    $564–816

  2. Train to South Bend, fly to Tocumen International Airport, bus

    cheapest
    1. Take the train from Van Buren St. to South Bend Airporttrain train
    2. Fly from South Bend (SBN) to Tocumen International Airport (PTY)plane plane SBN - PTY
    3. Take the bus from Paraíso, Panamá Province to Santiagobus bus
    17h 41m
    $264–825

  3. Drive 5,811.2 km

    1. Drive from Chicago to Santiagocar car 5,811.2 km
    3d 1h
    $795–1,149

  4. Fly Chicago O'Hare International Airport to David, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to David (DAV)plane plane ORD - DAV
    2. Take the bus from David to Santiagobus bus
    15h 5m

  5. Train to General Mitchell International Airport, fly to Tocumen International Airport, bus

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Tocumen International Airport (PTY)plane plane MKE - PTY
    3. Take the bus from Paraíso, Panamá Province to Santiagobus bus
    16h 40m
    $321–1,081

  6. Fly Chicago Midway International Airport to Tocumen International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Tocumen International Airport (PTY)plane plane MDW - PTY
    2. Take the bus from Paraíso, Panamá Province to Santiagobus bus
    15h 1m
    $264–866

  7. Fly Chicago O'Hare International Airport to Juan Santamaría International Airport, bus, shuttle

    1. Fly from Chicago O'Hare International Airport (ORD) to Juan Santamaría International Airport (SJO)plane plane ORD - SJO
    2. Take the bus from 50 m este Del Aeropuerto to Terminal San José Av. 2, C12 Y 14bus bus
    3. Take a shuttle bus from San José to Paso Canoasshuttle bus
    4. Take the bus from Paso Canoas to Santiago de Veraguasbus bus
    17h 4m
    $1,148–1,360

  8. Fly Chicago Midway International Airport to David, bus

    1. Fly from Chicago Midway International Airport (MDW) to David (DAV)plane plane MDW - DAV
    2. Take the bus from David to Santiagobus bus
    16h 46m

  9. Fly Chicago Midway International Airport to Juan Santamaría International Airport, bus, shuttle

    1. Fly from Chicago Midway International Airport (MDW) to Juan Santamaría International Airport (SJO)plane plane MDW - SJO
    2. Take the bus from 50 m este Del Aeropuerto to Terminal San José Av. 2, C12 Y 14bus bus
    3. Take a shuttle bus from San José to Paso Canoasshuttle bus
    4. Take the bus from Paso Canoas to Santiago de Veraguasbus bus
    18h 14m
    $988–1,610

Chicago O'Hare International Airport (ORD) to Tocumen International Airport (PTY) flights

Calendar48Weekly Planes
Duration7h 19mAverage Duration
Ticket$161Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Santiago.ExpandLaunch map view
  • Distance: 4,068.9 km
  • Duration: 13h 48m

What companies run services between Chicago, IL, USA and Santiago, Panama?

There is no direct connection from Chicago to Santiago. However, you can take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Tocumen International Airport (PTY), walk to Aeropuerto Internacional de Tocumen, take the shuttle to Paraíso, walk to Paraíso, Panamá Province, then take the bus to Santiago. Alternatively, you can drive from Chicago to Santiago in around 3d 1h.

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