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How to get fromChicago to Senecaby plane, taxi, bus, train (Amtrak), or car

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There are 7 ways to get from Chicago to Seneca by plane, taxi, bus, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport, taxi

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    2. Take the taxi from Greenville–Spartanburg International Airport (GSP) to Senecataxi taxi
    4h 50m
    $218–665

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Senecacar car
    5h 34m
    $70–354

  3. Bus, taxi

    1. Take the bus from Chicago Train Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Flying J - Commercebus bus
    3. Take the taxi from Flying J - Commerce to Senecataxi taxi
    20h 19m
    $222–365

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Charlottesvilletrain train Cardinal
    2. Take the train from Charlottesville to Clemson Amtrak Stationtrain train Crescent
    31h 7m
    $360–769

  5. Drive 676.4 mi

    1. Drive from Chicago to Senecacar car 676.4 mi
    13h 12m
    $124–179

  6. Fly Chicago Midway International Airport to Asheville Regional Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Asheville Regional Airport (AVL)plane plane MDW - AVL
    2. Drive from Asheville-Airport-AVL to Senecacar car
    7h 3m
    $110–514

  7. Bus, taxi via Atlanta

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Flying J - Commercebus bus
    3. Take the taxi from Flying J - Commerce to Senecataxi taxi
    20h 45m
    $224–368

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar62Weekly Planes
Duration3h 1mAverage Duration
Ticket$89Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Seneca.ExpandLaunch map view
  • Distance: 645.3 mi
  • Duration: 4h 50m

What companies run services between Chicago, IL, USA and Seneca, SC, USA?

You can take a train from Chicago Union Station to Seneca via Charlottesville and Clemson Amtrak Station in around 31h 7m.

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