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How to get fromChicago to South Carolinaby plane, bus, taxi, train (Amtrak), or car

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There are 10 ways to get from Chicago to South Carolina by plane, bus, taxi, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    4h 3m
    $132–600

  2. Fly Chicago O'Hare International Airport to Charleston International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    5h 9m
    $90–427

  3. Bus, taxi

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta to Savannahbus bus
    3. Take the bus from Bluffton Transfer Center to Walmartbus bus 320
    4. Take the taxi from Walmart to Dorchester Village Shopping Center Park & Ridetaxi taxi
    26h 5m

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 39m
    $435–871

  5. Drive 872.2 mi

    1. Drive from Chicago to Charlestoncar car 872.2 mi
    15h 59m
    $160–230

  6. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 21m
    $212–515

  7. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 4m
    $202–805

  8. Fly Chicago O'Hare International Airport to Asheville Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 39m
    $202–515

  9. Fly Chicago Midway International Airport to Charleston International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    4h 42m
    $104–557

  10. Fly Chicago O'Hare International Airport to Columbia

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    5h 16m
    $174–907

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar98Weekly Planes
Duration3h 7mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Chicago to South Carolina.ExpandLaunch map view
  • Distance: 608.1 mi
  • Duration: 4h 3m

What companies run services between Chicago, IL, USA and South Carolina, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a train from Chicago Union Station to Charleston via Petersburg Amtrak Station and Charleston Amtrak Station in around 28h 39m.

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