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How to get fromChicago to South Carolinaby plane, train (Amtrak), car, or taxi

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There are 9 ways to get from Chicago to South Carolina by plane, train (Amtrak), car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    3h 59m
    $122–550

  2. Fly Chicago O'Hare International Airport to Columbia

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    5h 14m
    $60–337

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train Floridian
    2. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor / ...
    28h 39m
    $731–1,119

  4. Drive  872.2 mi

    1. Drive from Chicago to Charlestoncar car 872.2 mi
    15h 59m
    $160–230

  5. Fly Chicago Midway International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Charlotte Douglas International Airport (CLT)plane plane MDW - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 59m
    $212–905

  6. Fly Chicago O'Hare International Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Charlotte Douglas International Airport (CLT)plane plane ORD - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    4h 22m
    $168–605

  7. Fly Chicago O'Hare International Airport to Asheville Regional Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 35m
    $192–485

  8. Fly Chicago Midway International Airport to Charleston International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Charleston International Airport (CHS)plane plane MDW - CHS
    4h 41m
    $114–657

  9. Fly Chicago O'Hare International Airport to Charleston International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Charleston International Airport (CHS)plane plane ORD - CHS
    5h 3m
    $504–857

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar87Weekly Planes
Duration2h 33mAverage Duration
Ticket$88Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to South Carolina.ExpandLaunch map view
  • Distance: 608.1 mi
  • Duration: 3h 59m

What companies run services between Chicago, IL, USA and South Carolina, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a train from Chicago Union Station to Charleston via Petersburg Amtrak Station and Charleston Amtrak Station in around 28h 39m.

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