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How to get fromChicago to Southern Illinois University Edwardsvilleby train (Amtrak), bus (Flixbus), car, plane, taxi, or train

Find Transport to Southern Illinois University Edwardsville

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There are 6 ways to get from Chicago to Southern Illinois University Edwardsville by train (Amtrak), bus (Flixbus), car, plane, taxi, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    5h 17m
    $135–245

  2. Drive 278.2 mi

    cheapest
    1. Drive from Chicago to Southern Illinois University Edwardsvillecar car 278.2 mi
    4h 45m
    $51–74

  3. Bus (Flixbus)

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    6h 26m
    $96–143

  4. Fly from Chicago O'Hare International Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the taxi from St-Louis-Airport-STL to Southern Illinois University Edwardsvilletaxi taxi
    3h 36m
    $338–785

  5. Fly from Chicago Midway International Airport, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    2. Take the taxi from St-Louis-Airport-STL to Southern Illinois University Edwardsvilletaxi taxi
    3h 20m
    $142–635

  6. Train to General Mitchell International Airport, fly, taxi

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    3. Take the taxi from St-Louis-Airport-STL to Southern Illinois University Edwardsvilletaxi taxi
    4h 53m
    $574–1,000

Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) flights

Calendar109Weekly Planes
Duration1h 28mAverage Duration
Ticket$62Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Southern Illinois University Edwardsville.ExpandLaunch map view
  • Distance: 301.5 mi
  • Duration: 5h 17m

What companies run services between Chicago, IL, USA and Southern Illinois University Edwardsville, IL, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $85–190 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station 4 times a day. Tickets cost $50–85 and the journey takes 5h 55m.

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