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How to get fromChicago to Spartanburgby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus (Flixbus)

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There are 7 ways to get from Chicago to Spartanburg by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    4h 12m
    $152–625

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    4h 41m
    $72–360

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta Bus Station to Greenvillebus bus Greyhound US0670
    20h 11m
    $209–355

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Carytrain train
    2. Take the train from Cary to Charlotte Amtrak Stationtrain train
    3. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    30h 50m
    $427–865

  5. Drive 672.3 mi

    1. Drive from Chicago to Spartanburgcar car 672.3 mi
    12h 45m
    $123–178

  6. Fly Chicago Midway International Airport to Asheville Regional Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Asheville Regional Airport (AVL)plane plane MDW - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    6h 23m
    $112–520

  7. Bus via Bloomington

    1. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    2. Take the bus from Bloomington to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Servicios Zapata - Spartanburgbus bus
    21h 47m
    $182–368

Chicago to Spartanburg by train (Amtrak)

Calendar7Weekly Trains
Duration30h 50mAverage Duration
Ticket$427Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Spartanburg.ExpandLaunch map view
  • Distance: 615 mi
  • Duration: 4h 12m

What companies run services between Chicago, IL, USA and Spartanburg, SC, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Chicago Bus Station to Spartanburg via Atlanta Bus Station and Greenville in around 20h 11m.

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