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How to get fromChicago to Spartanburgby plane, bus (Flixbus), train (Amtrak), car, or bus (Amtrak, Greyhound, Flixbus)

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There are 7 ways to get from Chicago to Spartanburg by plane, bus (Flixbus), train (Amtrak), car, or bus (Amtrak, Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    4h 9m
    $142–575

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    4h 34m
    $66–350

  3. Bus

    1. Take the bus from Chicago Bus Station to Bloomingtonbus bus
    2. Take the bus from Bloomington to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Servicios Zapata - Spartanburgbus bus
    21h 49m
    $152–249

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Carytrain train
    2. Take the train from Cary to Charlotte Amtrak Stationtrain train
    3. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    30h 50m
    $349–779

  5. Drive  672.3 mi

    1. Drive from Chicago to Spartanburgcar car 672.3 mi
    12h 45m
    $123–178

  6. Fly Chicago Midway International Airport to Asheville Regional Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Asheville Regional Airport (AVL)plane plane MDW - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    6h 30m
    $106–520

  7. Bus via Toledo

    1. Take the bus from Chicago Union Station to Toledobus bus
    2. Take the bus from Toledo Bus Stop to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Spartanburgbus bus
    21h 58m
    $188–311

Chicago to Spartanburg by train (Amtrak)

Calendar7Weekly Trains
Duration30h 50mAverage Duration
Ticket$349Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Spartanburg.ExpandLaunch map view
  • Distance: 615 mi
  • Duration: 4h 9m

What companies run services between Chicago, IL, USA and Spartanburg, SC, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a bus from Chicago Bus Station to Spartanburg via Bloomington, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Servicios Zapata - Spartanburg in around 21h 49m.

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