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How to get fromChicago to Syracuseby plane, train (Amtrak), bus (Greyhound), car, train, or bus

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There are 9 ways to get from Chicago to Syracuse by plane, train (Amtrak), bus (Greyhound), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Syracuse Hancock International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Syracuse Hancock International Airport (SYR)plane plane ORD - SYR
    5h 25m
    $124–663

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Syracuse Bus Stationbus bus Greyhound US0171
    15h
    $102–208

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    12h 58m
    $210–440

  4. Drive 676 mi

    1. Drive from Chicago to Syracusecar car 676 mi
    11h 32m
    $124–179

  5. Fly Chicago Midway International Airport to Syracuse Hancock International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Syracuse Hancock International Airport (SYR)plane plane MDW - SYR
    6h 45m
    $154–863

  6. Fly Chicago Midway International Airport to Rochester, train

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    5h 34m
    $172–947

  7. Fly Chicago O'Hare International Airport to Rochester, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane plane ORD - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    5h 59m
    $142–797

  8. Fly Chicago Midway International Airport to Buffalo Niagara International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    2. Take the bus from Buffalo Niagara International Airport to Syracuse Bus Stationbus bus
    6h 30m
    $190–465

  9. Fly Chicago O'Hare International Airport to Wilkes-Barre/Scranton International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Wilkes-Barre/Scranton International Airport (AVP)plane plane ORD - AVP
    2. Take the bus from Scranton to Syracuse Bus Stationbus bus
    7h 12m
    $134–500

Chicago to Syracuse by train (Amtrak)

Calendar14Weekly Trains
Duration12h 58mAverage Duration
Ticket$210Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Syracuse.ExpandLaunch map view
  • Distance: 634.6 mi
  • Duration: 5h 25m

What companies run services between Chicago, IL, USA and Syracuse, NY, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Syracuse Hancock International Airport (SYR) hourly. Alternatively, Amtrak operates a train from Chicago Union Station to Syracuse Regional Transportation Center twice daily. Tickets cost $210–440 and the journey takes 12h 58m.

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