Rome2Rio

How to get fromChicago to Wayneby subway, plane, train, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

Find Transport to Wayne

See all options

There are 13 ways to get from Chicago to Wayne by subway, plane, train, train (Amtrak), bus (Flixbus), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Philadelphia International Airport, train

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Philadelphia International Airport (PHL)plane plane MDW - PHL
    3. Take the train from Gray 30th St Station to Waynetrain train
    5h 11m
    $148–411

  2. Fly Chicago O'Hare International Airport to Lancaster, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Lancaster (LNS)plane plane ORD - LNS
    2. Drive from Lancaster-Airport-LNS to Waynecar car
    4h 58m
    $78–381

  3. Train via Washington (Amtrak)

    1. Take the train from Chicago Union Station to Rockville Amtraktrain train Floridian
    2. Take the train from Washington Union Station to 30th Street Stationtrain train Acela
    20h 18m
    $290–586

  4. Bus

    1. Take the bus from Chicago Bus Station to Allentownbus bus FlixBus N2640
    2. Take the bus from Allentown Transportation Center to Philadelphia 30th St Stationbus bus Wilkes-Barre / ...
    22h 30m
    $174–276

  5. Drive 742.8 mi

    1. Drive from Chicago to Waynecar car 742.8 mi
    12h 9m
    $136–196

  6. Fly Chicago O'Hare International Airport to Philadelphia International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Philadelphia International Airport (PHL)plane plane ORD - PHL
    2. Take the train from Gray 30th St Station to Waynetrain train
    5h 30m
    $108–561

  7. Fly Chicago Midway International Airport to Baltimore-Washington International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Baltimore-Washington International Airport (BWI)plane plane MDW - BWI
    2. Take the train from BWI Thurgood Marshall to 30th Street Stationtrain train
    6h 37m
    $150–960

  8. Fly Chicago Midway International Airport to Laguardia Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Laguardia Airport (LGA)plane plane MDW - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    6h 58m
    $208–1,164

  9. Fly Chicago Midway International Airport to Ronald Reagan Washington National Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Ronald Reagan Washington National Airport (DCA)plane plane MDW - DCA
    2. Take the train from Washington Union Station to 30th Street Stationtrain train
    6h 42m
    $180–805

  10. Fly Chicago O'Hare International Airport to Lehigh Valley International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Lehigh Valley International Airport (ABE)plane plane ORD - ABE
    2. Take the bus from Allentown Transportation Center to Philadelphia 30th St Stationbus bus
    8h 11m
    $106–426

  11. Fly Chicago O'Hare International Airport to Harrisburg International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT)plane plane ORD - MDT
    2. Take the train from Harrisburg to Paoli Amtrak Stationtrain train
    7h 29m
    $98–425

  12. Bus via Baltimore

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0164
    2. Take the bus from Baltimore to Philadelphiabus bus Ppb 3613 / ...
    22h 41m
    $147–291

  13. Train (Amtrak)

    1. Take the train from Chicago Union Station to 30th Street Stationtrain train Cardinal
    26h 55m
    $344–685

Chicago to Wayne by train and subway (Amtrak)

Calendar7Weekly Services
Duration20h 18mAverage Duration
Ticket$290Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chicago to Wayne.ExpandLaunch map view
  • Distance: 698.4 mi
  • Duration: 5h 11m

What companies run services between Chicago, IL, USA and Wayne, PA, USA?

You can take a train from Chicago Union Station to Wayne via Rockville Amtrak, Rockville, Red Line Center Platform, Union Station, Red Line Center Platform, Washington Union Station, and Gray 30th St Station in around 20h 18m. Alternatively, you can take a bus from Chicago Bus Station to Lancaster Av & Wayne Av via Allentown, Allentown Transportation Center, Philadelphia 30th St Station, Market St & 30th St - FS, 69th St Transit Center South Terminal, and 69th St Transit Center North Terminal in around 22h 30m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers