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How to get fromChicago to Wayneby subway, plane, train, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

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There are 12 ways to get from Chicago to Wayne by subway, plane, train, train (Amtrak), bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Philadelphia International Airport, train

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Philadelphia International Airport (PHL)plane plane MDW - PHL
    3. Take the train from Gray 30th St Station to Waynetrain train
    5h 11m
    $148–383

  2. Fly Chicago O'Hare International Airport to Lancaster, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Lancaster (LNS)plane plane ORD - LNS
    2. Drive from Lancaster-Airport-LNS to Waynecar car
    4h 57m
    $68–351

  3. Train via Washington (Amtrak)

    1. Take the train from Chicago Union Station to Rockville Amtraktrain train Floridian
    2. Take the train from Washington Union Station to 30th Street Stationtrain train Acela
    20h 18m
    $247–626

  4. Bus (Flixbus)

    1. Take the bus from Chicago Bus Station to Philadelphia Bus Stationbus bus FlixBus N2642
    22h 47m
    $144–216

  5. Drive  742.8 mi

    1. Drive from Chicago to Waynecar car 742.8 mi
    12h 8m
    $136–196

  6. Fly Chicago O'Hare International Airport to Philadelphia International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Philadelphia International Airport (PHL)plane plane ORD - PHL
    2. Take the train from Gray 30th St Station to Waynetrain train
    5h 35m
    $128–233

  7. Fly Chicago Midway International Airport to Baltimore-Washington International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Baltimore-Washington International Airport (BWI)plane plane MDW - BWI
    2. Take the train from BWI Thurgood Marshall to 30th Street Stationtrain train
    6h 37m
    $150–961

  8. Fly Chicago Midway International Airport to Laguardia Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Laguardia Airport (LGA)plane plane MDW - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    7h 3m
    $228–1,265

  9. Fly Chicago Midway International Airport to Ronald Reagan Washington National Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Ronald Reagan Washington National Airport (DCA)plane plane MDW - DCA
    2. Take the train from Washington Union Station to 30th Street Stationtrain train
    6h 43m
    $164–811

  10. Fly Chicago O'Hare International Airport to Harrisburg International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Harrisburg International Airport (MDT)plane plane ORD - MDT
    2. Take the train from Harrisburg to Paoli Amtrak Stationtrain train
    7h 28m
    $82–391

  11. Bus via Baltimore (Greyhound)

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus Greyhound US0164
    2. Take the bus from Baltimore Greyhound Garage to Philadelphia Bus Stationbus bus Greyhound US0305
    25h 10m
    $154–240

  12. Train (Amtrak)

    1. Take the train from Chicago Union Station to 30th Street Stationtrain train Cardinal
    26h 55m
    $291–733

Chicago to Wayne by train and subway (Amtrak)

Calendar7Weekly Services
Duration20h 18mAverage Duration
Ticket$247Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Wayne.ExpandLaunch map view
  • Distance: 698.4 mi
  • Duration: 5h 11m

What companies run services between Chicago, IL, USA and Wayne, PA, USA?

You can take a train from Chicago Union Station to Wayne via Rockville Amtrak, Rockville, Red Line Center Platform, Union Station, Red Line Center Platform, Washington Union Station, and Gray 30th St Station in around 20h 18m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to Philadelphia Bus Station 4 times a week. Tickets cost $130–210 and the journey takes 20h 10m.

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