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How to get fromChicago to West Senecaby subway, plane, bus, train (Amtrak), car, or bus (Greyhound)

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There are 8 ways to get from Chicago to West Seneca by subway, plane, bus, train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Subway to Chicago Midway International Airport, fly to Buffalo Niagara International Airport, line 15 bus

    best
    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)plane plane MDW - BUF
    3. Take the bus from Lower Terrace & Adams Mark to Seneca Street & Cazenovia Parkwaybus bus
    4h 52m
    $166–346

  2. Bus

    cheapest
    1. Take the bus from Chicago to Clevelandbus bus Chicago
    2. Take the bus from Cleveland, OH to Buffalo, NYbus bus Cinncinati,OH-Buffalo
    12h 4m
    $54–141

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    10h 35m
    $181–364

  4. Drive 528.6 mi

    1. Drive from Chicago to West Senecacar car 528.6 mi
    8h 58m
    $97–140

  5. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport, line 15 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)plane plane ORD - BUF
    2. Take the bus from Lower Terrace & Adams Mark to Seneca Street & Cazenovia Parkwaybus bus
    5h 18m
    $176–336

  6. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)plane plane MDW - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 44m
    $162–800

  7. Fly Chicago O'Hare International Airport to Rochester, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)plane plane ORD - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 10m
    $132–650

  8. Bus via Brook Park (Greyhound)

    1. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus Greyhound US0164
    2. Take the bus from Cleveland Bus Station to Buffalobus bus Greyhound US0171 / ...
    12h 40m
    $81–152

Chicago to West Seneca by bus and foot

Calendar7Weekly Services
Duration12h 4mAverage Duration
Ticket$54Cheapest Price
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Questions & Answers

Map of how to get from Chicago to West Seneca.ExpandLaunch map view
  • Distance: 497.6 mi
  • Duration: 4h 52m

What companies run services between Chicago, IL, USA and West Seneca, NY, USA?

Amtrak operates a train from Chicago Union Station to Buffalo Depew Station twice daily. Tickets cost $150–340 and the journey takes 10h 23m. Alternatively, you can take a bus from Chicago to Seneca Street & Maywood Place via Cleveland, OH, Buffalo, NY, and Lower Terrace & Adams Mark in around 12h 4m.

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