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How to get fromChicago to Wiseby plane, car, bus, train, or subway

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There are 9 ways to get from Chicago to Wise by plane, car, bus, train, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Tri-Cities Regional Tn/Va Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ORD - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    5h 13m
    $58–320

  2. Bus, drive

    1. Take the bus from Chicago Bus Station to Washington Union Stationbus bus
    2. Take the bus from Washington Union Station to Bristol Exit 5 Park & Ride Lotbus bus
    3. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    27h 1m
    $190–272

  3. Train, subway, bus, drive

    1. Take the train from Chicago Union Station to Rockville Amtraktrain train
    2. Take the subway from Metro Center, Blue/Orange/Silver Line Center Platform to Washington Dulles International Airport, Silver Line Center Platformsubway subway S
    3. Take the bus from Dulles International Airport to Bristol Exit 5 Park & Ride Lotbus bus
    4. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    27h 17m
    $478–717

  4. Drive  524.7 mi

    1. Drive from Chicago to Wisecar car 524.7 mi
    9h 48m
    $96–139

  5. Fly Chicago Midway International Airport to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane MDW - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    7h 5m
    $102–570

  6. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Wisecar car
    6h 50m
    $72–325

  7. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Wisecar car
    6h 53m
    $146–790

  8. Fly Chicago O'Hare International Airport to Yeager Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Yeager Airport (CRW)plane plane ORD - CRW
    2. Drive from Yeager Airport (CRW) to Wisecar car
    7h 15m
    $76–340

  9. Train, bus, drive

    1. Take the train from Chicago Union Station to Charlottesvilletrain train
    2. Take the train from Charlottesville to Roanoketrain train
    3. Take the bus from Roanoke Amtrak Station to Exit 118 - Park and Ridebus bus Swb
    4. Take the bus from Christiansburg to Bristol Exit 5 Park & Ride Lotbus bus
    5. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    30h 49m
    $539–824

Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI) flights

Calendar24Weekly Planes
Duration3h 50mAverage Duration
Ticket$49Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Wise.ExpandLaunch map view
  • Distance: 552.6 mi
  • Duration: 5h 13m

What companies run services between Chicago, IL, USA and Wise, VA, USA?

There is no direct connection from Chicago to Wise. However, you can take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Tri-Cities Regional Tn/Va Airport (TRI), then drive to Wise. Alternatively, you can take a bus from Chicago Bus Station to Wise via Washington Union Station and Bristol Exit 5 Park & Ride Lot in around 27h 1m.

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