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How to get fromChicago to Wiseby plane, car, bus, or train

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There are 8 ways to get from Chicago to Wise by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Tri-Cities Regional Tn/Va Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ORD - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    5h 10m
    $62–330

  2. Bus, drive

    1. Take the bus from Chicago to Limabus bus
    2. Take the bus from Lima to Columbusbus bus
    3. Take the bus from Columbus to Wythevillebus bus
    4. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    5. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    20h 49m
    $112–251

  3. Train, bus, drive

    1. Take the train from Chicago Union Station to Ashland Amtrak Stationtrain train
    2. Take the bus from Ashland to Wythevillebus bus
    3. Take the bus from Wytheville Rural King Parking Lot to Bristol Exit 5 Park & Ride Lotbus bus
    4. Drive from Bristol Exit 5 Park & Ride Lot to Wisecar car
    21h 9m
    $184–394

  4. Drive  524.7 mi

    1. Drive from Chicago to Wisecar car 524.7 mi
    9h 48m
    $96–139

  5. Fly Chicago Midway International Airport to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane MDW - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    6h 58m
    $98–510

  6. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Wisecar car
    6h 43m
    $136–740

  7. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Wisecar car
    6h 51m
    $72–345

  8. Fly Chicago O'Hare International Airport to Yeager Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Yeager Airport (CRW)plane plane ORD - CRW
    2. Drive from Yeager Airport (CRW) to Wisecar car
    7h 8m
    $90–450

Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI) flights

Calendar21Weekly Planes
Duration2h 42mAverage Duration
Ticket$51Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Wise.ExpandLaunch map view
  • Distance: 552.6 mi
  • Duration: 5h 10m

What companies run services between Chicago, IL, USA and Wise, VA, USA?

There is no direct connection from Chicago to Wise. However, you can take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Tri-Cities Regional Tn/Va Airport (TRI), then drive to Wise. Alternatively, you can take a bus from Chicago to Wise via Lima, Columbus, Wytheville, Wytheville Rural King Parking Lot, and Bristol Exit 5 Park & Ride Lot in around 20h 49m.

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