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How to get fromChillicothe to St. Louisby car, train, bus (Amtrak, Flixbus), plane, or bus

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There are 6 ways to get from Chillicothe to St. Louis by car, train, bus (Amtrak, Flixbus), plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train (Amtrak)

    best
    1. Drive from Chillicothe to Bloomington-Normalcar car
    2. Take the train from Bloomington-Normal to St. Louistrain train Lincoln Service / ...
    3h 51m
    $60–124

  2. Drive 185.1 mi

    cheapest
    1. Drive from Chillicothe to St. Louiscar car 185.1 mi
    3h 10m
    $34–49

  3. Bus

    1. Take the bus from Peoria Amtrak Station to Springfieldbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus FlixBus 2510 / ...
    6h 14m
    $88–119

  4. Fly from Peoria International Airport

    1. Fly from Peoria International Airport (PIA) to Lambert–St. Louis International Airport (STL)plane plane PIA - STL
    4h 59m
    $157–557

  5. Bus, train (Amtrak)

    1. Take the bus from Peoria Amtrak Station to Springfieldbus bus Amtrak Thruway Connecting Service
    2. Take the train from Springfield to St. Louistrain train Lincoln Service / ...
    4h 32m
    $113–171

  6. Drive to Central Illinois Regional Airport At Bloomington-Normal, fly

    1. Drive from Chillicothe to Bloomington-Airport-BMIcar car
    2. Fly from Central Illinois Regional Airport At Bloomington-Normal (BMI) to Lambert–St. Louis International Airport (STL)plane plane BMI - STL
    5h 21m
    $89–469

Peoria International Airport (PIA) to Lambert–St. Louis International Airport (STL) flights

Calendar78Weekly Planes
Duration5h 31mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

Map of how to get from Chillicothe to St. Louis.ExpandLaunch map view
  • Distance: 211.9 mi
  • Duration: 3h 51m

What companies run services between Chillicothe, IL, USA and St. Louis, MO, USA?

You can take a vehicle from Chillicothe to St Louis Bus Station via EP!C/Peoria Production, CityLink Transit Center, Peoria Amtrak Station, Springfield, Washington & 4th, and Springfield SMTD Transfer Center in around 6h 14m. Alternatively, United Airlines and American Airlines fly from Peoria International Airport (PIA) to Lambert–St. Louis International Airport (STL) every 2 hours.

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