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How to get fromChillicothe to Chicagoby car, train, shuttle, or plane

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There are 5 ways to get from Chillicothe to Chicago by car, train, shuttle, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, train (Amtrak)

    best
    1. Drive from Chillicothe to La Plata Stationcar car
    2. Take the train from La Plata Station to Chicago Union Stationtrain train Southwest Chief
    7h 2m
    $105–221

  2. Drive 415.9 mi

    cheapest
    1. Drive from Chillicothe to Chicagocar car 415.9 mi
    7h 16m
    $76–110

  3. Drive, shuttle to Columbia Regional Airport, fly to Chicago O'Hare International Airport

    1. Drive from Chillicothe to Maconcar car
    2. Take a shuttle bus from Macon to Columbiashuttle bus
    3. Fly from Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD)plane plane COU - ORD
    5h 40m
    $106–341

  4. Shuttle to Kansas City, fly to Chicago Midway International Airport

    1. Take a shuttle bus from Chillicothe to Kansas Cityshuttle bus
    2. Fly from Kansas City (MCI) to Chicago Midway International Airport (MDW)plane plane MCI - MDW
    6h 34m
    $76–441

  5. Shuttle to Kansas City, fly to Chicago O'Hare International Airport

    1. Take a shuttle bus from Chillicothe to Kansas Cityshuttle bus
    2. Fly from Kansas City (MCI) to Chicago O'Hare International Airport (ORD)plane plane MCI - ORD
    7h 2m
    $356–761

Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD) flights

Calendar42Weekly Planes
Duration1h 42mAverage Duration
Ticket$40Cheapest Price
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Questions & Answers

Map of how to get from Chillicothe to Chicago.ExpandLaunch map view
  • Distance: 377.1 mi
  • Duration: 7h 2m

What companies run services between Chillicothe, MO, USA and Chicago, IL, USA?

There is no direct connection from Chillicothe to Chicago. However, you can drive to La Plata Station then take the train to Chicago Union Station. Alternatively, you can drive from Chillicothe to Chicago in around 7h 16m.

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