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How to get fromChillicothe to St. Louisby shuttle, bus, train, car, or plane

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There are 4 ways to get from Chillicothe to St. Louis by shuttle, bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle, bus

    best
    1. Take a shuttle bus from Chillicothe to Kansas Cityshuttle bus to Kansas City
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    7h 17m
    $39–81

  2. Shuttle, train

    1. Take a shuttle bus from Chillicothe to Kansas Cityshuttle bus to Kansas City
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    8h 45m
    $89–196

  3. Drive 232.6 mi

    1. Drive from Chillicothe to St. Louiscar car 232.6 mi
    4h 12m
    $43–62

  4. Shuttle, fly

    1. Take a shuttle bus from Chillicothe to Kansas Cityshuttle bus
    2. Fly from Kansas City (MCI) to Lambert–St. Louis International Airport (STL)plane plane MCI - STL
    6h 15m
    $92–609

Kansas City (MCI) to Lambert–St. Louis International Airport (STL) flights

Calendar20Weekly Planes
Duration1h 2mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Chillicothe to St. Louis.ExpandLaunch map view
  • Distance: 338.4 mi
  • Duration: 7h 17m

What companies run services between Chillicothe, MO, USA and St. Louis, MO, USA?

There is no direct connection from Chillicothe to St. Louis. However, you can take the shuttle to Kansas City, walk to On Grand At 9Th Southbound Farside, take the line 201 bus to On 13Th Between Charlotte & Holmes Wb, walk to Kansas City Bus Station, then take the bus to St Louis Bus Station. Alternatively, you can take a shuttle from Chillicothe to St. Louis via Kansas City, North Loop, Union Station, and Kansas City in around 8h 45m.

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