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How to get fromChillicothe to Chicagoby bus, plane, train, car, or bus (Flixbus)

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There are 10 ways to get from Chillicothe to Chicago by bus, plane, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to John Glenn Columbus International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW)plane plane CMH - MDW
    5h 19m
    $69–463

  2. Bus

    cheapest
    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus - Mound St to Chicagobus bus Columbus / ...
    9h 52m
    $41–123

  3. Bus, train via Toledo

    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus
    2. Take the bus from Columbus - Mound St to Toledobus bus
    3. Take the train from Toledo to Chicago Union Stationtrain train
    10h 40m
    $101–243

  4. Drive 363.2 mi

    1. Drive from Chillicothe to Chicagocar car 363.2 mi
    6h 25m
    $67–96

  5. Bus to John Glenn Columbus International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Chicago O'Hare International Airport (ORD)plane plane CMH - ORD
    5h 42m
    $564–983

  6. Bus to Yeager Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Chillicothe to Charleston, WVbus bus
    2. Fly from Yeager Airport (CRW) to Chicago O'Hare International Airport (ORD)plane plane CRW - ORD
    7h 14m
    $90–419

  7. Bus to Covington, fly to Chicago Midway International Airport

    1. Take the bus from Piketon to University of Cincinnatibus bus
    2. Fly from Covington (CVG) to Chicago Midway International Airport (MDW)plane plane CVG - MDW
    6h 42m
    $213–474

  8. Bus to Covington, fly to Chicago O'Hare International Airport

    1. Take the bus from Piketon to University of Cincinnatibus bus
    2. Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane plane CVG - ORD
    7h 10m
    $213–964

  9. Bus via Columbus

    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus to Chicago Bus Stationbus bus FlixBus 2511 / ...
    9h 57m
    $68–141

  10. Bus, train

    1. Take the bus from Chillicothe to Ashlandbus bus Columbus
    2. Take the train from Ashland Amtrak Station to Chicago Union Stationtrain train Cardinal
    15h 13m
    $154–358

John Glenn Columbus International Airport (CMH) to Chicago Midway International Airport (MDW) flights

Calendar27Weekly Planes
Duration1h 13mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Chillicothe to Chicago.ExpandLaunch map view
  • Distance: 347.8 mi
  • Duration: 5h 19m

What companies run services between Chillicothe, OH, USA and Chicago, IL, USA?

You can take a vehicle from Chillicothe to Chicago via Chillicothe and Columbus - Mound St in around 9h 52m.

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