Rome2Rio

How to get fromChillicothe to St. Louisby bus, plane, bus (Greyhound), or car

Find Transport to St. Louis

See all options

There are 4 ways to get from Chillicothe to St. Louis by bus, plane, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to John Glenn Columbus International Airport, fly

    best
    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    5h 35m
    $815–981

  2. Bus

    cheapest
    1. Take the bus from Chillicothe to Columbus - Mound Stbus bus Charlotte
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    11h 17m
    $71–163

  3. Drive 428 mi

    1. Drive from Chillicothe to St. Louiscar car 428 mi
    7h 21m
    $79–113

  4. Bus to Covington, fly

    1. Take the bus from Piketon to University of Cincinnatibus bus
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    8h 53m
    $664–1,062

John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL) flights

Calendar32Weekly Planes
Duration2h 42mAverage Duration
Ticket$103Cheapest Price
See schedules

Questions & Answers

Map of how to get from Chillicothe to St. Louis.ExpandLaunch map view
  • Distance: 477.4 mi
  • Duration: 5h 35m

What companies run services between Chillicothe, OH, USA and St. Louis, MO, USA?

You can take a vehicle from Chillicothe to St Louis Bus Station via Chillicothe and Columbus in around 11h 17m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers