Rome2Rio

How to get fromCincinnati to Mayo Clinicby plane, bus (Flixbus), car, or bus

Find Transport to Mayo Clinic

See all options

There are 5 ways to get from Cincinnati to Mayo Clinic by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Covington to Rochester

    best
    1. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 58m
    $102–642

  2. Bus

    1. Take the bus from Cincinnati to Madisonbus bus FlixBus 2514
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    15h 16m
    $122–181

  3. Drive  632.7 mi

    1. Drive from Cincinnati to Mayo Cliniccar car 632.7 mi
    10h 42m
    $109–157

  4. Fly Covington to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 48m
    $442–1,152

  5. Drive to Louisville International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Drive from Cincinnati to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 19m
    $153–556

Cincinnati to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration15h 16mAverage Duration
Ticket$122Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Cincinnati to Mayo Clinic.ExpandLaunch map view
  • Distance: 548.7 mi
  • Duration: 6h 58m

What companies run services between Cincinnati, OH, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Covington (CVG) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Cincinnati to Mayo Clinic via Madison and Rochester in around 15h 16m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Booking & Getting There