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How to get fromCincinnati to Mayo Clinicby plane, bus (Flixbus), car, or bus

Find Transport to Mayo Clinic

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There are 5 ways to get from Cincinnati to Mayo Clinic by plane, bus (Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Covington to Rochester

    best
    1. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 42m
    $98–592

  2. Bus

    1. Take the bus from Cincinnati to Madisonbus bus FlixBus 2514
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    15h 18m
    $119–177

  3. Drive  632.7 mi

    1. Drive from Cincinnati to Mayo Cliniccar car 632.7 mi
    10h 44m
    $116–167

  4. Fly Covington to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 44m
    $502–1,152

  5. Drive to Louisville International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Drive from Cincinnati to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 14m
    $169–678

Cincinnati to Mayo Clinic by bus and foot

Calendar6Weekly Services
Duration15h 18mAverage Duration
Ticket$119Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cincinnati to Mayo Clinic.ExpandLaunch map view
  • Distance: 548.8 mi
  • Duration: 6h 42m

What companies run services between Cincinnati, OH, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Covington (CVG) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Cincinnati to Mayo Clinic via Madison and Rochester in around 15h 18m.

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