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How to get fromClarksville to Chicagoby car, plane, bus (Amtrak), bus, train, or bus (Amtrak, Greyhound)

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There are 8 ways to get from Clarksville to Chicago by car, plane, bus (Amtrak), bus, train, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Clarksville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 51m
    $75–414

  2. Line 72 bus to Louisville International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Eastern @ Brooks to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    5h 4m
    $50–311

  3. Bus (Amtrak)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    7h 38m
    $52–63

  4. Bus, train via Speedway

    1. Take the bus from El Mercadito Grocery - Clarksville, IN to Indianapolisbus bus Memphis
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 21m
    $107–269

  5. Drive 291.1 mi

    1. Drive from Clarksville to Chicagocar car 291.1 mi
    4h 58m
    $54–77

  6. Line 72 bus to Louisville International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Eastern @ Brooks to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    4h 32m
    $55–361

  7. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus Greyhound US0100 / ...
    8h 33m
    $51–103

  8. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 58m
    $84–178

Clarksville to Chicago by bus and foot (Amtrak)

Calendar14Weekly Services
Duration7h 38mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

Map of how to get from Clarksville to Chicago.ExpandLaunch map view
  • Distance: 414.4 mi
  • Duration: 3h 51m

What companies run services between Clarksville, Clark County, IN, USA and Chicago, IL, USA?

Amtrak Thruway operates a bus from Louisville, KY to Chicago Union Station twice daily. Tickets cost $50–60 and the journey takes 6h.

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